Development of 3D Printed Multi-Layered Orodispersible Films
with Porous Structure Applicable as a Substrate for Inkjet
Printing

J 2023

Development of 3D Printed Multi-Layered Orodispersible Films with Porous Structure Applicable as a Substrate for Inkjet Printing

ELBL, Jan, Martin VESELÝ, Dagmar BLAHÁČKOVÁ, Jaroslav ONDRUS, Pavel KULICH et. al.

Basic information

Original name

Development of 3D Printed Multi-Layered Orodispersible Films with Porous Structure Applicable as a Substrate for Inkjet Printing

Authors

ELBL, Jan (203 Czech Republic, belonging to the institution), Martin VESELÝ (203 Czech Republic, belonging to the institution), Dagmar BLAHÁČKOVÁ (203 Czech Republic, belonging to the institution), Jaroslav ONDRUS, Pavel KULICH, Eliska MASKOVA, Josef MASEK and Jan GAJDZIOK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Pharmaceutics, Basel, MDPI, 2023, 1999-4923

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.400 in 2022

RIV identification code

RIV/00216224:14160/23:00130562

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.3390/pharmaceutics15020714

UT WoS

000940009800001

Keywords in English

oral films; fast dissolving films; porous films; 3D print; inkjet print; individualized therapy

Abstract

V originále

The direct tailoring of the size, composition, or number of layers belongs to the advantages of 3D printing employment in producing orodispersible films (ODFs) compared to the frequently utilized solvent casting method. This study aimed to produce porous ODFs as a substrate for medicated ink deposited by a 2D printer. The innovative semi-solid extrusion 3D printing method was employed to produce multilayered ODFs, where the bottom layer assures the mechanical properties. In contrast, the top layer provides a porous structure for ink entrapment. Hydroxypropyl methylcellulose and polyvinyl alcohol were utilized as film-forming polymers, glycerol as a plasticizer, and sodium starch glycolate as a disintegrant in the bottom matrix. Several porogen agents (Aeroperl® 300, Fujisil®, Syloid® 244 FP, Syloid® XDP 3050, Neusilin® S2, Neusilin® US2, and Neusilin® UFL2) acted as porosity enhancers in the two types of top layer. ODFs with satisfactory disintegration time were prepared. The correlation between the porogen content and the mechanical properties was proved. A porous ODF structure was detected in most samples and linked to the porogen content. SSE 3D printing represents a promising preparation method for the production of porous ODFs as substrates for subsequent drug deposition by 2D printing, avoiding the difficulties arising in casting or printing medicated ODFs directly.

Links

MUNI/A/1151/2021, interní kód MU

Name: Optimalizácia matricových filmov pripravených 3D tlačou ako substrátov pre depozíciu liečiv (Acronym: printing filmy)

Investor: Masaryk University

Citovat

ELBL, Jan, Martin VESELÝ, Dagmar BLAHÁČKOVÁ, Jaroslav ONDRUS, Pavel KULICH, Eliska MASKOVA, Josef MASEK and Jan GAJDZIOK. Development of 3D Printed Multi-Layered Orodispersible Films with Porous Structure Applicable as a Substrate for Inkjet Printing. Pharmaceutics. Basel: MDPI, 2023, vol. 15, No 2, p. 1-15. ISSN 1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics15020714.

@article{2273699,
   author = {Elbl, Jan and Veselý, Martin and Blaháčková, Dagmar and Ondrus, Jaroslav and Kulich, Pavel and Maskova, Eliska and Masek, Josef and Gajdziok, Jan},
   article_location = {Basel},
   article_number = {2},
   doi = {http://dx.doi.org/10.3390/pharmaceutics15020714},
   keywords = {oral films; fast dissolving films; porous films; 3D print; inkjet print; individualized therapy},
   language = {eng},
   issn = {1999-4923},
   journal = {Pharmaceutics},
   title = {Development of 3D Printed Multi-Layered Orodispersible Films with Porous Structure Applicable as a Substrate for Inkjet Printing},
   url = {https://www.mdpi.com/1999-4923/15/2/714},
   volume = {15},
   year = {2023}
}

TY  - JOUR
ID  - 2273699
AU  - Elbl, Jan - Veselý, Martin - Blaháčková, Dagmar - Ondrus, Jaroslav - Kulich, Pavel - Maskova, Eliska - Masek, Josef - Gajdziok, Jan
PY  - 2023
TI  - Development of 3D Printed Multi-Layered Orodispersible Films with Porous Structure Applicable as a Substrate for Inkjet Printing
JF  - Pharmaceutics
VL  - 15
IS  - 2
SP  - 1-15
EP  - 1-15
PB  - MDPI
SN  - 19994923
KW  - oral films
KW  - fast dissolving films
KW  - porous films
KW  - 3D print
KW  - inkjet print
KW  - individualized therapy
UR  - https://www.mdpi.com/1999-4923/15/2/714
N2  - The direct tailoring of the size, composition, or number of layers belongs to the advantages of 3D printing employment in producing orodispersible films (ODFs) compared to the frequently utilized solvent casting method. This study aimed to produce porous ODFs as a substrate for medicated ink deposited by a 2D printer. The innovative semi-solid extrusion 3D printing method was employed to produce multilayered ODFs, where the bottom layer assures the mechanical properties. In contrast, the top layer provides a porous structure for ink entrapment. Hydroxypropyl methylcellulose and polyvinyl alcohol were utilized as film-forming polymers, glycerol as a plasticizer, and sodium starch glycolate as a disintegrant in the bottom matrix. Several porogen agents (Aeroperl® 300, Fujisil®, Syloid® 244 FP, Syloid® XDP 3050, Neusilin® S2, Neusilin® US2, and Neusilin® UFL2) acted as porosity enhancers in the two types of top layer. ODFs with satisfactory disintegration time were prepared. The correlation between the porogen content and the mechanical properties was proved. A porous ODF structure was detected in most samples and linked to the porogen content. SSE 3D printing represents a promising preparation method for the production of porous ODFs as substrates for subsequent drug deposition by 2D printing, avoiding the difficulties arising in casting or printing medicated ODFs directly.
ER  -

ELBL, Jan, Martin VESELÝ, Dagmar BLAHÁČKOVÁ, Jaroslav ONDRUS, Pavel KULICH, Eliska MASKOVA, Josef MASEK and Jan GAJDZIOK. Development of 3D Printed Multi-Layered Orodispersible Films with Porous Structure Applicable as a Substrate for Inkjet Printing. \textit{Pharmaceutics}. Basel: MDPI, 2023, vol.~15, No~2, p.~1-15. ISSN~1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics15020714.

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