ŠIMEK, Matěj, Kristýna TURKOVÁ, Martin SCHWARZER, Kristina NEŠPOROVÁ, Lukáš KUBALA, Martina HERMANNOVÁ, Tereza FOGLOVÁ, Barbora ŠAFRÁNKOVÁ, Martin ŠINDELÁŘ, Dagmar ŠRŮTKOVÁ, Sofia CHATZIGEORGIOU, Tereza NOVOTNÁ, Tomáš HUDCOVIC and Vladimír VELEBNÝ. Molecular weight and gut microbiota determine the bioavailability of orally administered hyaluronic acid. Carbohydrate Polymers. Elsevier, 2023, vol. 313, August, p. 1-13. ISSN 0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2023.120880. |
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@article{2274717, author = {Šimek, Matěj and Turková, Kristýna and Schwarzer, Martin and Nešporová, Kristina and Kubala, Lukáš and Hermannová, Martina and Foglová, Tereza and Šafránková, Barbora and Šindelář, Martin and Šrůtková, Dagmar and Chatzigeorgiou, Sofia and Novotná, Tereza and Hudcovic, Tomáš and Velebný, Vladimír}, article_number = {August}, doi = {http://dx.doi.org/10.1016/j.carbpol.2023.120880}, keywords = {Microbiota; Hyaluronan; Metabolism; Bioavailability; Digestion; Oligosaccharides}, language = {eng}, issn = {0144-8617}, journal = {Carbohydrate Polymers}, title = {Molecular weight and gut microbiota determine the bioavailability of orally administered hyaluronic acid}, url = {https://doi.org/10.1016/j.carbpol.2023.120880}, volume = {313}, year = {2023} }
TY - JOUR ID - 2274717 AU - Šimek, Matěj - Turková, Kristýna - Schwarzer, Martin - Nešporová, Kristina - Kubala, Lukáš - Hermannová, Martina - Foglová, Tereza - Šafránková, Barbora - Šindelář, Martin - Šrůtková, Dagmar - Chatzigeorgiou, Sofia - Novotná, Tereza - Hudcovic, Tomáš - Velebný, Vladimír PY - 2023 TI - Molecular weight and gut microbiota determine the bioavailability of orally administered hyaluronic acid JF - Carbohydrate Polymers VL - 313 IS - August SP - 1-13 EP - 1-13 PB - Elsevier SN - 01448617 KW - Microbiota KW - Hyaluronan KW - Metabolism KW - Bioavailability KW - Digestion KW - Oligosaccharides UR - https://doi.org/10.1016/j.carbpol.2023.120880 N2 - The ability of hyaluronan as a dietary supplement to increase skin moisture and relieve knee pain has been demonstrated in several clinical studies. To understand the mechanism of action, determining hyaluronan's bioavailability and in vivo fate is crucial. Here, we used 13C-hyaluronan combined with LC–MS analysis to compare the absorption and metabolism of oral hyaluronan in germ-free and conventional wild-type mice. The presence of Bacteroides spp. in the gut was crucial for hyaluronan absorption. Specific microorganisms cleave hyaluronan into unsaturated oligosaccharides (<3 kDa) which are partially absorbed through the intestinal wall. The remaining hyaluronan fragments are metabolized into short-chain fatty acids, which are only metabolites available to the host. The poor bioavailability (~0.2 %) of oral hyaluronan indicates that the mechanism of action is the result of the systematic regulatory function of hyaluronan or its metabolites rather than the direct effects of hyaluronan at distal sites of action (skin, joints). ER -
ŠIMEK, Matěj, Kristýna TURKOVÁ, Martin SCHWARZER, Kristina NEŠPOROVÁ, Lukáš KUBALA, Martina HERMANNOVÁ, Tereza FOGLOVÁ, Barbora ŠAFRÁNKOVÁ, Martin ŠINDELÁŘ, Dagmar ŠRŮTKOVÁ, Sofia CHATZIGEORGIOU, Tereza NOVOTNÁ, Tomáš HUDCOVIC and Vladimír VELEBNÝ. Molecular weight and gut microbiota determine the bioavailability of orally administered hyaluronic acid. \textit{Carbohydrate Polymers}. Elsevier, 2023, vol.~313, August, p.~1-13. ISSN~0144-8617. Available from: https://dx.doi.org/10.1016/j.carbpol.2023.120880.
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