Detailed Information on Publication Record
2023
Stability of thymol self-emulsifying chitosan pellets for the potential treatment of intestinal mucosa
MACKŮ, Jan, Kateřina KUBOVÁ, Martina ČUBOVÁ URBANOVÁ, Jiří BRUS, Jan MUSELÍK et. al.Basic information
Original name
Stability of thymol self-emulsifying chitosan pellets for the potential treatment of intestinal mucosa
Name in Czech
Stabilita samoemulgujících chitosanových pelet s obsahem thymolu pro potenciální léčbu střevní sliznice
Authors
MACKŮ, Jan (203 Czech Republic, belonging to the institution), Kateřina KUBOVÁ (203 Czech Republic, guarantor, belonging to the institution), Martina ČUBOVÁ URBANOVÁ (203 Czech Republic), Jiří BRUS (203 Czech Republic), Jan MUSELÍK (203 Czech Republic, belonging to the institution), Daniela HLAVATÁ (203 Czech Republic, belonging to the institution), Miroslava PAVELKOVÁ (203 Czech Republic, belonging to the institution), Sylvie PAVLOKOVÁ (203 Czech Republic, belonging to the institution), Jakub VYSLOUŽIL (203 Czech Republic, belonging to the institution) and David VETCHÝ (203 Czech Republic, belonging to the institution)
Edition
4th European Conference on Pharmaceutics -20&21 March 2023, Marseille – France, 2023
Other information
Language
English
Type of outcome
Prezentace na konferencích
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14160/23:00134100
Organization unit
Faculty of Pharmacy
Keywords (in Czech)
thymol; pevné samoemulgující systémy; ssNMR; pelety; stabilita
Keywords in English
thymol; solid self-emulsifying systems; ssNMR; pellets; stability
Tags
International impact
Změněno: 14/4/2023 14:58, doc. PharmDr. Kateřina Kubová, Ph.D.
V originále
The aim of the presented experimental study was to determine the stability of the Eugragit®L-coated chitosan/ Neusilin®US2 pellets containing thymol SEDDS. The first results confirmed the stability of uncoated self-emulsifying pellets with thymol in a half-year stability study in both storage conditions. On the contrary, the enteric-coated pellet formulation was stable only in the condition 25 °C/ 60 RH. Moreover, a mild deterioration of dissolution characteristics was reported.
In Czech
Cílem předložené experimentální studie bylo stanovit stabilitu pelet na bázi chitosanu a Neusilinu®US2 obalených Eugragitem®L, které obsahovaly SEDDS s thymolem. První výsledky potvrdily stabilitu neobalených samoemulgujících pelet v půlroční stabilitní studii v obou skladovacích podmínkách. Naopak, pelety obalené enterosolventním obalem byly stabilní pouze v podmínkách 25 °C/ 60 RH. Navíc bylo zaznamenáno mírné zhoršení disolučních vlastností.
Links
| GA22-03187S, research and development project |
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