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@proceedings{2275210, author = {Pavelková, Miroslava and Kubová, Kateřina and Muselík, Jan and Vysloužil, Jakub and Čubová Urbanová, Martina and Brus, Jiří and Vetchý, David}, booktitle = {4th European Conference on Pharmaceutics -20&21 March 2023, Marseille – France}, keywords = {alginate; chitosan; hydrogel particles; self-emulsifying system; thymol}, language = {eng}, title = {Alginate/chitosan hydrogel particles for site-specific thymol delivery to the colon}, year = {2023} }
TY - CONF ID - 2275210 AU - Pavelková, Miroslava - Kubová, Kateřina - Muselík, Jan - Vysloužil, Jakub - Čubová Urbanová, Martina - Brus, Jiří - Vetchý, David PY - 2023 TI - Alginate/chitosan hydrogel particles for site-specific thymol delivery to the colon KW - alginate KW - chitosan KW - hydrogel particles KW - self-emulsifying system KW - thymol N2 - This work aimed to formulate composite hydrogel particles based on two oppositely charged polymers, sodium alginate, and chitosan, prepared by external ion gelation. The dosage form formulation as a self-emulsifying system (SES) carrier was targeted to deliver the insoluble drug thymol to the GIT distal parts. The impact of several formulation variables (the proportional amount of sodium tripolyphosphate and sodium alginate, a type of chitosan, and the amount of incorporated SES on morphological properties, swelling properties, thymol content, and in vitro dissolution profiles over 6 hours were investigated. The most prolonged thymol release was ensured using a higher ratio of tripolyphosphate to sodium alginate and primarily with a higher incorporated SES amount. However, a deeper study on possible use in treating intestinal inflammations is necessary. ER -
PAVELKOVÁ, Miroslava, Kateřina KUBOVÁ, Jan MUSELÍK, Jakub VYSLOUŽIL, Martina ČUBOVÁ URBANOVÁ, Jiří BRUS and David VETCHÝ. Alginate/chitosan hydrogel particles for site-specific thymol delivery to the colon. In \textit{4th European Conference on Pharmaceutics -20\&{}21 March 2023, Marseille – France}. 2023.
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