Detailed Information on Publication Record
2023
Spray-dried microparticles containing ciprofloxacin for pulmonary delivery
PEŠTÁLOVÁ, Andrea, Sylvie PAVLOKOVÁ and Jan GAJDZIOKBasic information
Original name
Spray-dried microparticles containing ciprofloxacin for pulmonary delivery
Authors
PEŠTÁLOVÁ, Andrea (203 Czech Republic, belonging to the institution), Sylvie PAVLOKOVÁ (203 Czech Republic, belonging to the institution) and Jan GAJDZIOK (203 Czech Republic, belonging to the institution)
Edition
Student scientific conference MUNI PHARM 2023, 2023
Other information
Language
English
Type of outcome
Prezentace na konferencích
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14160/23:00130642
Organization unit
Faculty of Pharmacy
Keywords (in Czech)
mikročástice; sprejové sušení; ciprofloxacin; cystická fibróza
Keywords in English
microparticles; spray drying; ciprofloxacin; cystic fibrosis
Změněno: 7/11/2023 12:49, JUDr. Sabina Krejčiříková
Abstract
V originále
Inhalation therapy of cystic fibrosis using a dry powder inhaler (DPI) is currently being studied in many clinical trials. One possible treatment option is the administration of fluroqinolones in the treatment of P. aeruginosa infections and have been proven to reduce the bacterial load in the lungs and improve patients’ lung function. In order for antibiotic therapy to be effective, the formulation should focus on the parameters particles should have, especially their size and shape, porosity or aerosolisation properties. For the formulation of dry powders, the most common are spray technologies and also the addition of excipients such as porogens or substances from the amino acid group can modify the resulting properties. The aim was to optimize the drying conditions to produce aerodynamically suitable particles. In the next step, particles containing ciprofloxacin were formulated. The resulting particles were evaluated in terms of morphology, flow properties and geometric or aerodynamic diameter respectively.
Links
| MUNI/A/1140/2021, interní kód MU |
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