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@article{2278171,
author = {Hradilek, Pavel and Revendova Zondra, Kamila Zondra and Horakova, Jana and Bunganic, Radovan and Pelíšek, Ondřej and Zeman, David and Hanzlikova, Pavla and Kusnierova, Pavlina},
article_location = {Olomouc},
article_number = {1},
doi = {http://dx.doi.org/10.5507/bp.2023.002},
keywords = {multiple sclerosis; biomarkers; neurofilament light chain; CXCL13; clinical course},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers, Olomouc: Palacky University},
title = {Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosis},
url = {https://biomed.papers.upol.cz/artkey/bio-202301-0005_cerebrospinal-fluid-neurofilament-light-chains-and-cxcl13-as-predictive-factors-for-clinical-course-of-multiple.php},
volume = {167},
year = {2023}
}
TY - JOUR
ID - 2278171
AU - Hradilek, Pavel - Revendova Zondra, Kamila Zondra - Horakova, Jana - Bunganic, Radovan - Pelíšek, Ondřej - Zeman, David - Hanzlikova, Pavla - Kusnierova, Pavlina
PY - 2023
TI - Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosis
JF - Biomedical Papers, Olomouc: Palacky University
VL - 167
IS - 1
SP - 30-35
EP - 30-35
PB - Palacky University
SN - 12138118
KW - multiple sclerosis
KW - biomarkers
KW - neurofilament light chain
KW - CXCL13
KW - clinical course
UR - https://biomed.papers.upol.cz/artkey/bio-202301-0005_cerebrospinal-fluid-neurofilament-light-chains-and-cxcl13-as-predictive-factors-for-clinical-course-of-multiple.php
N2 - Aim. The aim of this study was to identify whether NfL and CXCL13 cerebrospinal fluid (CSF) concentrations at diagnos-tic lumbar puncture can predict the course of multiple sclerosis (MS) in terms of relapses, higher expanded disability status scale (EDSS) and magnetic resonance imaging (MRI) activity.Methods. We conducted a single-centre prospective observational cohort study at the MS center, University Hospital Ostrava, Czech Republic. CSF NfL (cNfL) and CXCL13 concentrations were examined (ELISA method) in patients with clinically isolated syndrome (CIS) and relapsing-remitting MS (RRMS) at the time of diagnostic lumbar puncture.Results. A total of 44 patients with CIS or early RRMS were enrolled, 31 (70.5%) of whom were women. The median age at the time of CSF sampling was 31.21 years (IQR 25.43-39.32), and the follow-up period was 54.6 months (IQR 44.03 - 59.48). In the simple and multiple logistic regression models, CXCL13 levels did not predict relapses, MRI activ-ity or EDSS > 2.5. Similarly, cNfL concentrations did not predict relapses or MRI activity in either model. In the multiple regression, higher cNfL levels were associated with reaching EDSS > 2.5 (odds ratio [OR] 1.002, 95% confidence interval [CI] 1.000 to 1.003).Conclusions. Our data did not confirm cNfL and/or CXCL13 CSF levels were predictive factors for disease activity such as relapses and MRI activity at the time of diagnostic lumbar puncture in patients with RRMS. While cNfL CSF levels predicted higher disability only after adjustment for other known risk factors, elevated CSF CXCL13 did not predict higher disability at all.
ER -
HRADILEK, Pavel, Kamila Zondra REVENDOVA ZONDRA, Jana HORAKOVA, Radovan BUNGANIC, Ondřej PELÍŠEK, David ZEMAN, Pavla HANZLIKOVA and Pavlina KUSNIEROVA. Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosis. \textit{Biomedical Papers, Olomouc: Palacky University}. Olomouc: Palacky University, 2023, vol.~167, No~1, p.~30-35. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2023.002.
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