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@article{2278173,
author = {Gadanec, Laura Kate and McSweeney, Kristen Renee and Kubatka, Peter and Caprnda, Martin and Gaspar, Ludovit and Prosecký, Robert and Dragasek, Jozef and Kružliak, Peter and Apostolopoulos, Vasso and Zulli, Anthony},
article_location = {DORDRECHT},
article_number = {2},
doi = {http://dx.doi.org/10.1007/s11010-023-04724-0},
keywords = {Abdominal aortic aneurysm; Angiotensin II; Angiotensin type 1 receptor; Angiotensin type 2 receptor; Vasoconstriction},
language = {eng},
issn = {0300-8177},
journal = {MOLECULAR AND CELLULAR BIOCHEMISTRY},
title = {Angiotensin II constricts mouse iliac arteries: possible mechanism for aortic aneurysms},
url = {https://link.springer.com/article/10.1007/s11010-023-04724-0},
volume = {479},
year = {2024}
}
TY - JOUR
ID - 2278173
AU - Gadanec, Laura Kate - McSweeney, Kristen Renee - Kubatka, Peter - Caprnda, Martin - Gaspar, Ludovit - Prosecký, Robert - Dragasek, Jozef - Kružliak, Peter - Apostolopoulos, Vasso - Zulli, Anthony
PY - 2024
TI - Angiotensin II constricts mouse iliac arteries: possible mechanism for aortic aneurysms
JF - MOLECULAR AND CELLULAR BIOCHEMISTRY
VL - 479
IS - 2
SP - 233-242
EP - 233-242
PB - SPRINGER
SN - 03008177
KW - Abdominal aortic aneurysm
KW - Angiotensin II
KW - Angiotensin type 1 receptor
KW - Angiotensin type 2 receptor
KW - Vasoconstriction
UR - https://link.springer.com/article/10.1007/s11010-023-04724-0
N2 - Abdominal aortic aneurysms (AAA) result from maladaptive remodeling of the vascular wall and reduces structural integrity. Angiotensin II (AngII) infusion has become a standard laboratory model for studying AAA initiation and progression. We determined the different vasoactive responses of various mouse arteries to Ang II. Ex vivo isometric tension analysis was conducted on 18-week-old male C57BL/6 mice (n = 4) brachiocephalic arteries (BC), iliac arteries (IL), and abdominal (AA) and thoracic aorta (TA). Arterial rings were mounted between organ hooks, gently stretched and an AngII dose response was performed. Rings were placed in 4% paraformaldehyde for immunohistochemistry analysis to quantify peptide expression of angiotensin type 1 (AT(1)R) and 2 receptors (AT(2)R) in the endothelium, media, and adventitia. Results from this study demonstrated vasoconstriction responses in IL were significantly higher at all AngII doses when compared to BC, and TA and AA responses (maximum constriction-IL: 68.64 +/- 5.47% vs. BC: 1.96 +/- 1.00%; TA: 3.13 +/- 0.16% and AA: 2.75 +/- 1.77%, p < 0.0001). Expression of AT(1)R was highest in the endothelium of IL (p < 0.05) and in the media and (p < 0.05) adventitia (p < 0.05) of AA. In contrast, AT(2)R expression was highest in endothelium (p < 0.05), media (p < 0.01, p < 0.05) and adventitia of TA. These results suggest that mouse arteries display different vasoactive responses to AngII, and the exaggerated response in IL arteries may play a role during AAA development.
ER -
GADANEC, Laura Kate, Kristen Renee MCSWEENEY, Peter KUBATKA, Martin CAPRNDA, Ludovit GASPAR, Robert PROSECKÝ, Jozef DRAGASEK, Peter KRUŽLIAK, Vasso APOSTOLOPOULOS and Anthony ZULLI. Angiotensin II constricts mouse iliac arteries: possible mechanism for aortic aneurysms. \textit{MOLECULAR AND CELLULAR BIOCHEMISTRY}. DORDRECHT: SPRINGER, 2024, vol.~479, No~2, p.~233-242. ISSN~0300-8177. Available from: https://dx.doi.org/10.1007/s11010-023-04724-0.
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