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@article{2278219,
author = {Hluchanova, Alzbeta and Kollar, Branislav and Klobucnikova, Katarina and Hardonova, Miroslava and Poddany, Michal and Zitnanova, Ingrid and Dvorakova, Monika and Konarikova, Katarina and Tedla, Miroslav and Urík, Milan and Klail, Pavel and Skopek, Petr and Turcani, Peter and Siarnik, Pavel},
article_location = {BASEL},
article_number = {2},
doi = {http://dx.doi.org/10.3390/life13020441},
keywords = {lipoprotein subfractions; obstructive sleep apnea; polysomnography},
language = {eng},
issn = {2075-1729},
journal = {LIFE-BASEL},
title = {Lipoprotein Subfractions Associated with Endothelial Function in Previously Healthy Subjects with Newly Diagnosed Sleep Apnea-A Pilot Study},
url = {https://www.mdpi.com/2075-1729/13/2/441},
volume = {13},
year = {2023}
}
TY - JOUR
ID - 2278219
AU - Hluchanova, Alzbeta - Kollar, Branislav - Klobucnikova, Katarina - Hardonova, Miroslava - Poddany, Michal - Zitnanova, Ingrid - Dvorakova, Monika - Konarikova, Katarina - Tedla, Miroslav - Urík, Milan - Klail, Pavel - Skopek, Petr - Turcani, Peter - Siarnik, Pavel
PY - 2023
TI - Lipoprotein Subfractions Associated with Endothelial Function in Previously Healthy Subjects with Newly Diagnosed Sleep Apnea-A Pilot Study
JF - LIFE-BASEL
VL - 13
IS - 2
SP - 1-11
EP - 1-11
PB - MDPI
SN - 20751729
KW - lipoprotein subfractions
KW - obstructive sleep apnea
KW - polysomnography
UR - https://www.mdpi.com/2075-1729/13/2/441
N2 - Background: Obstructive sleep apnea (OSA) activates several pathophysiological mechanisms which can lead to the development of vascular diseases. Endothelial dysfunction (ED) is an initial step in the development of atherosclerosis. The association between ED and OSA has been described in several studies, even in previously healthy subjects. High-density lipoproteins (HDL) were generally considered to be atheroprotective, and low-density lipoprotein (LDL) to be an atherogenic component of lipoproteins. However, recent findings suggest a pro-atherogenic role of small HDL subfractions (8-10) and LDL subfractions (3-7). This study aimed to evaluate the relationship between endothelial function and lipid subfractions in previously healthy OSA subjects. Material and Methods: We prospectively enrolled 205 subjects with sleep monitoring. Plasma levels of triacylglycerols, total cholesterol, LDL, HDL, and their subfractions were assessed. Endothelial function was determined using peripheral arterial tonometry, and reperfusion hyperemia index (RHI) was assessed. Results: Plasma levels of small and intermediate HDL subfractions have statistically significant pro-atherogenic correlations with endothelial function (p = 0.015 and p = 0.019). In other lipoprotein levels, no other significant correlation was found with RHI. In stepwise multiple linear regression analysis, small HDL (beta = -0.507, p = 0.032) was the only significant contributor in the model predicting RHI. Conclusions: In our studied sample, a pro-atherogenic role of small HDL subfractions in previously healthy subjects with moderate-to-severe OSA was proven.
ER -
HLUCHANOVA, Alzbeta, Branislav KOLLAR, Katarina KLOBUCNIKOVA, Miroslava HARDONOVA, Michal PODDANY, Ingrid ZITNANOVA, Monika DVORAKOVA, Katarina KONARIKOVA, Miroslav TEDLA, Milan URÍK, Pavel KLAIL, Petr SKOPEK, Peter TURCANI and Pavel SIARNIK. Lipoprotein Subfractions Associated with Endothelial Function in Previously Healthy Subjects with Newly Diagnosed Sleep Apnea-A Pilot Study. \textit{LIFE-BASEL}. BASEL: MDPI, 2023, vol.~13, No~2, p.~1-11. ISSN~2075-1729. Available from: https://dx.doi.org/10.3390/life13020441.
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