Lipoprotein Subfractions Associated with Endothelial Function
in Previously Healthy Subjects with Newly Diagnosed Sleep
Apnea-A Pilot Study

J 2023

Lipoprotein Subfractions Associated with Endothelial Function in Previously Healthy Subjects with Newly Diagnosed Sleep Apnea-A Pilot Study

HLUCHANOVA, Alzbeta, Branislav KOLLAR, Katarina KLOBUCNIKOVA, Miroslava HARDONOVA, Michal PODDANY et. al.

Basic information

Original name

Lipoprotein Subfractions Associated with Endothelial Function in Previously Healthy Subjects with Newly Diagnosed Sleep Apnea-A Pilot Study

Authors

Edition

LIFE-BASEL, BASEL, MDPI, 2023, 2075-1729

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30206 Otorhinolaryngology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.200 in 2022

RIV identification code

RIV/00216224:14110/23:00130663

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/life13020441

UT WoS

000941407900001

Keywords in English

lipoprotein subfractions; obstructive sleep apnea; polysomnography

Abstract

V originále

Background: Obstructive sleep apnea (OSA) activates several pathophysiological mechanisms which can lead to the development of vascular diseases. Endothelial dysfunction (ED) is an initial step in the development of atherosclerosis. The association between ED and OSA has been described in several studies, even in previously healthy subjects. High-density lipoproteins (HDL) were generally considered to be atheroprotective, and low-density lipoprotein (LDL) to be an atherogenic component of lipoproteins. However, recent findings suggest a pro-atherogenic role of small HDL subfractions (8-10) and LDL subfractions (3-7). This study aimed to evaluate the relationship between endothelial function and lipid subfractions in previously healthy OSA subjects. Material and Methods: We prospectively enrolled 205 subjects with sleep monitoring. Plasma levels of triacylglycerols, total cholesterol, LDL, HDL, and their subfractions were assessed. Endothelial function was determined using peripheral arterial tonometry, and reperfusion hyperemia index (RHI) was assessed. Results: Plasma levels of small and intermediate HDL subfractions have statistically significant pro-atherogenic correlations with endothelial function (p = 0.015 and p = 0.019). In other lipoprotein levels, no other significant correlation was found with RHI. In stepwise multiple linear regression analysis, small HDL (beta = -0.507, p = 0.032) was the only significant contributor in the model predicting RHI. Conclusions: In our studied sample, a pro-atherogenic role of small HDL subfractions in previously healthy subjects with moderate-to-severe OSA was proven.

Citovat

HLUCHANOVA, Alzbeta, Branislav KOLLAR, Katarina KLOBUCNIKOVA, Miroslava HARDONOVA, Michal PODDANY, Ingrid ZITNANOVA, Monika DVORAKOVA, Katarina KONARIKOVA, Miroslav TEDLA, Milan URÍK, Pavel KLAIL, Petr SKOPEK, Peter TURCANI and Pavel SIARNIK. Lipoprotein Subfractions Associated with Endothelial Function in Previously Healthy Subjects with Newly Diagnosed Sleep Apnea-A Pilot Study. LIFE-BASEL. BASEL: MDPI, 2023, vol. 13, No 2, p. 1-11. ISSN 2075-1729. Available from: https://dx.doi.org/10.3390/life13020441.

@article{2278219,
   author = {Hluchanova, Alzbeta and Kollar, Branislav and Klobucnikova, Katarina and Hardonova, Miroslava and Poddany, Michal and Zitnanova, Ingrid and Dvorakova, Monika and Konarikova, Katarina and Tedla, Miroslav and Urík, Milan and Klail, Pavel and Skopek, Petr and Turcani, Peter and Siarnik, Pavel},
   article_location = {BASEL},
   article_number = {2},
   doi = {http://dx.doi.org/10.3390/life13020441},
   keywords = {lipoprotein subfractions; obstructive sleep apnea; polysomnography},
   language = {eng},
   issn = {2075-1729},
   journal = {LIFE-BASEL},
   title = {Lipoprotein Subfractions Associated with Endothelial Function in Previously Healthy Subjects with Newly Diagnosed Sleep Apnea-A Pilot Study},
   url = {https://www.mdpi.com/2075-1729/13/2/441},
   volume = {13},
   year = {2023}
}

TY  - JOUR
ID  - 2278219
AU  - Hluchanova, Alzbeta - Kollar, Branislav - Klobucnikova, Katarina - Hardonova, Miroslava - Poddany, Michal - Zitnanova, Ingrid - Dvorakova, Monika - Konarikova, Katarina - Tedla, Miroslav - Urík, Milan - Klail, Pavel - Skopek, Petr - Turcani, Peter - Siarnik, Pavel
PY  - 2023
TI  - Lipoprotein Subfractions Associated with Endothelial Function in Previously Healthy Subjects with Newly Diagnosed Sleep Apnea-A Pilot Study
JF  - LIFE-BASEL
VL  - 13
IS  - 2
SP  - 1-11
EP  - 1-11
PB  - MDPI
SN  - 20751729
KW  - lipoprotein subfractions
KW  - obstructive sleep apnea
KW  - polysomnography
UR  - https://www.mdpi.com/2075-1729/13/2/441
N2  - Background: Obstructive sleep apnea (OSA) activates several pathophysiological mechanisms which can lead to the development of vascular diseases. Endothelial dysfunction (ED) is an initial step in the development of atherosclerosis. The association between ED and OSA has been described in several studies, even in previously healthy subjects. High-density lipoproteins (HDL) were generally considered to be atheroprotective, and low-density lipoprotein (LDL) to be an atherogenic component of lipoproteins. However, recent findings suggest a pro-atherogenic role of small HDL subfractions (8-10) and LDL subfractions (3-7). This study aimed to evaluate the relationship between endothelial function and lipid subfractions in previously healthy OSA subjects. Material and Methods: We prospectively enrolled 205 subjects with sleep monitoring. Plasma levels of triacylglycerols, total cholesterol, LDL, HDL, and their subfractions were assessed. Endothelial function was determined using peripheral arterial tonometry, and reperfusion hyperemia index (RHI) was assessed. Results: Plasma levels of small and intermediate HDL subfractions have statistically significant pro-atherogenic correlations with endothelial function (p = 0.015 and p = 0.019). In other lipoprotein levels, no other significant correlation was found with RHI. In stepwise multiple linear regression analysis, small HDL (beta = -0.507, p = 0.032) was the only significant contributor in the model predicting RHI. Conclusions: In our studied sample, a pro-atherogenic role of small HDL subfractions in previously healthy subjects with moderate-to-severe OSA was proven.
ER  -

HLUCHANOVA, Alzbeta, Branislav KOLLAR, Katarina KLOBUCNIKOVA, Miroslava HARDONOVA, Michal PODDANY, Ingrid ZITNANOVA, Monika DVORAKOVA, Katarina KONARIKOVA, Miroslav TEDLA, Milan URÍK, Pavel KLAIL, Petr SKOPEK, Peter TURCANI and Pavel SIARNIK. Lipoprotein Subfractions Associated with Endothelial Function in Previously Healthy Subjects with Newly Diagnosed Sleep Apnea-A Pilot Study. \textit{LIFE-BASEL}. BASEL: MDPI, 2023, vol.~13, No~2, p.~1-11. ISSN~2075-1729. Available from: https://dx.doi.org/10.3390/life13020441.

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