ČUNDRLE, Ivan, Zdeněk MERTA, Monika BRATOVÁ, Pavel HOMOLKA, Ladislav MITÁŠ, Vladimír ŠRÁMEK, Michal SVOBODA, Zdeněk CHOVANEC, Miloš CHOBOLA, Lyle J. OLSON and Kristián BRAT. The risk of post-operative pulmonary complications in lung resection candidates with normal forced expiratory volume in 1 s and diffusing capacity of the lung for carbon monoxide: a prospective multicentre study. ERJ open research. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2023, vol. 9, No 2, p. 1-9. ISSN 2312-0541. Available from: https://dx.doi.org/10.1183/23120541.00421-2022.
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Basic information
Original name The risk of post-operative pulmonary complications in lung resection candidates with normal forced expiratory volume in 1 s and diffusing capacity of the lung for carbon monoxide: a prospective multicentre study
Authors ČUNDRLE, Ivan (203 Czech Republic, belonging to the institution), Zdeněk MERTA (203 Czech Republic, belonging to the institution), Monika BRATOVÁ (203 Czech Republic, belonging to the institution), Pavel HOMOLKA (203 Czech Republic), Ladislav MITÁŠ (203 Czech Republic, belonging to the institution), Vladimír ŠRÁMEK (203 Czech Republic, belonging to the institution), Michal SVOBODA (203 Czech Republic, belonging to the institution), Zdeněk CHOVANEC (203 Czech Republic, belonging to the institution), Miloš CHOBOLA (203 Czech Republic, belonging to the institution), Lyle J. OLSON and Kristián BRAT (703 Slovakia, guarantor, belonging to the institution).
Edition ERJ open research, SHEFFIELD, EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2023, 2312-0541.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30203 Respiratory systems
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.600 in 2022
RIV identification code RIV/00216224:14110/23:00130703
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1183/23120541.00421-2022
UT WoS 000947843200012
Keywords in English lung resection; post-operative pulmonary complications; carbon monoxide
Tags 14110120, 14110122, 14110215, 14110223, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 19/2/2024 08:43.
Abstract
Introduction According to the guidelines for preoperative assessment of lung resection candidates, patients with normal forced expiratory volume in 1 s (FEV1) and diffusing capacity of the lung for carbon monoxide (DLCO) are at low risk for post-operative pulmonary complications (PPC). However, PPC affect hospital length of stay and related healthcare costs. We aimed to assess risk of PPC for lung resection candidates with normal FEV1 and D-LCO (>80% predicted) and identify factors associated with PPC. Methods 398 patients were prospectively studied at two centres between 2017 and 2021. PPC were recorded from the first 30 post-operative days. Subgroups of patients with and without PPC were compared and factors with significant difference were analysed by uni- and multivariate logistic regression. Results 188 subjects had normal FEV1 and D-LCO. Of these, 17 patients (9%) developed PPC. Patients with PPC had significantly lower pressure of end-tidal carbon dioxide (P-ETCO2) at rest (27.7 versus 29.9; p=0.033) and higher ventilatory efficiency (V'(E)/V'(CO2)) slope (31.1 versus 28; p=0.016) compared to those without PPC. Multivariate models showed association between resting P-ETCO2 (OR 0.872; p=0.035) and V'(E)/V'(CO2) slope (OR 1.116; p=0.03) and PPC. In both models, thoracotomy was strongly associated with PPC (OR 6.419; p=0.005 and OR 5.884; p=0.007, respectively). Peak oxygen consumption failed to predict PPC ( p=0.917). Conclusions Resting P-ETCO2 adds incremental information for risk prediction of PPC in patients with normal FEV1 and D-LCO. We propose resting P-ETCO2 be an additional parameter to FEV1 and D-LCO for preoperative risk stratification.
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