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@article{2279582,
author = {Fülöpová, Nicole and Chomova, Natalia and Elbl, Jan and Mudronova, Dagmar and Sivulič, Patrik and Pavloková, Sylvie and Franc, Aleš},
article_location = {Basel},
article_number = {3},
doi = {http://dx.doi.org/10.3390/pharmaceutics15030910},
keywords = {lyophilization; antropozoonoses; probiotic bacteria; individual treatment; principal component analysis; viability of bacteria},
language = {eng},
issn = {1999-4923},
journal = {Pharmaceutics},
title = {Preparation and Evaluation of a Dosage Form for Individualized Administration of Lyophilized Probiotics},
url = {https://www.mdpi.com/1999-4923/15/3/910},
volume = {15},
year = {2023}
}
TY - JOUR
ID - 2279582
AU - Fülöpová, Nicole - Chomova, Natalia - Elbl, Jan - Mudronova, Dagmar - Sivulič, Patrik - Pavloková, Sylvie - Franc, Aleš
PY - 2023
TI - Preparation and Evaluation of a Dosage Form for Individualized Administration of Lyophilized Probiotics
JF - Pharmaceutics
VL - 15
IS - 3
SP - 1-19
EP - 1-19
PB - MDPI
SN - 19994923
KW - lyophilization
KW - antropozoonoses
KW - probiotic bacteria
KW - individual treatment
KW - principal component analysis
KW - viability of bacteria
UR - https://www.mdpi.com/1999-4923/15/3/910
N2 - Probiotics have been used in human and veterinary medicine to increase resistance to pathogens and provide protection against external impacts for many years. Pathogens are often transmitted to humans through animal product consumption. Therefore, it is assumed that probiotics protecting animals may also protect the humans who consume them. Many tested strains of probiotic bacteria can be used for individualized therapy. The recently isolated Lactobacillus plantarum R2 Biocenol™ has proven to be preferential in aquaculture, and potential benefits in humans are expected. A simple oral dosage form should be developed to test this hypothesis by a suitable preparation method, i.e., lyophilization, allowing the bacteria to survive longer. Lyophilizates were formed from silicates (Neusilin® NS2N; US2), cellulose derivates (Avicel® PH-101), and saccharides (inulin; saccharose; modified starch® 1500). They were evaluated for their physicochemical properties (pH leachate, moisture content, water absorption, wetting time, DSC tests, densities, and flow properties); their bacterial viability was determined in conditions including relevant studies over 6 months at 4 °C and scanned under an electron microscope. Lyophilizate composed of Neusilin® NS2N and saccharose appeared to be the most advantageous in terms of viability without any significant decrease. Its physicochemical properties are also suitable for capsule encapsulation, subsequent clinical evaluation, and individualized therapy.
ER -
FÜLÖPOVÁ, Nicole, Natalia CHOMOVA, Jan ELBL, Dagmar MUDRONOVA, Patrik SIVULIČ, Sylvie PAVLOKOVÁ and Aleš FRANC. Preparation and Evaluation of a Dosage Form for Individualized Administration of Lyophilized Probiotics. \textit{Pharmaceutics}. Basel: MDPI, 2023, vol.~15, No~3, p.~1-19. ISSN~1999-4923. Available from: https://dx.doi.org/10.3390/pharmaceutics15030910.
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