Detailed Information on Publication Record
2023
Prognostic Properties of the GOLD 2023 Classification System
BRAT, Kristián, Michal SVOBODA, Jaromir ZATLOUKAL, Marek PLUTINSKÝ, Eva VOLAKOVA et. al.Basic information
Original name
Prognostic Properties of the GOLD 2023 Classification System
Authors
BRAT, Kristián (703 Slovakia, guarantor, belonging to the institution), Michal SVOBODA (203 Czech Republic), Jaromir ZATLOUKAL (203 Czech Republic), Marek PLUTINSKÝ (703 Slovakia, belonging to the institution), Eva VOLAKOVA (203 Czech Republic), Patrice POPELKOVA (203 Czech Republic), Barbora NOVOTNA (203 Czech Republic), Tomas DVORAK (203 Czech Republic) and Vladimir KOBLIZEK (203 Czech Republic)
Edition
International Journal of chronic obstructive pulmonary disease, Albany, Dove Medical Press Ltd. 2023, 1178-2005
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30203 Respiratory systems
Country of publisher
New Zealand
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.800 in 2022
RIV identification code
RIV/00216224:14110/23:00130744
Organization unit
Faculty of Medicine
UT WoS
000975875800001
Keywords in English
GOLD classification; COPD; mortality; prognosis
Tags
International impact, Reviewed
Změněno: 20/6/2023 09:46, Mgr. Tereza Miškechová
Abstract
V originále
Introduction: Recently, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) has published an update on the Global Strategy for Prevention, Diagnosis and Management of COPD, introducing a new classification of chronic obstructive pulmonary disease (COPD). Our aim was to assess the prognostic value of the new GOLD classification system in comparison with the previous GOLD classification systems (GOLD stages I-IV and GOLD groups A-D) and the BODE index.Methods: We used the data of 784 patients with COPD from the Czech Multicenter Research Database of COPD. Patient survival was analyzed with the use of Kaplan-Meier estimate and Cox model of proportional risks. ROC analysis and area under curve (AUC) were used for comparison of GOLD classifications and BODE index. The analyses were performed with the use of software R (version 4.2.0).Results: We analyzed data of 782 patients with complete data on GOLD classifications. The study population comprised 72.9% of men, 89.1% current or former smokers, with a mean age of 66.6 years, a mean BMI of 27.4 and a mean FEV1 44.9% of predicted. Probability of 5-year survival differed by GOLD classification. Application of the 2023 GOLD classification showed increased risk of death in group B (HR 1.82, 95% CI 1.14-2.92; p = 0.013) and in group E (HR 2.48, 95% CI 1.54-3.99; p<0.001). The ROC analysis showed that the overall prognostic value of the 2023 GOLD classification was similarly weak to previous A-D GOLD classification schemes (AUCs 0.557-0.576) and was lower compared to the GOLD 1-4 system (AUC 0.614) and even lower when compared to the BODE index (AUC 0.715).Conclusion: We concluded that the new GOLD classification system has poor prognostic properties and that specific prediction tools (eg, the BODE index) should be used for mortality risk assessment.