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@article{2281377,
author = {Brat, Kristián and Svoboda, Michal and Zatloukal, Jaromir and Plutinský, Marek and Volakova, Eva and Popelkova, Patrice and Novotna, Barbora and Dvorak, Tomas and Koblizek, Vladimir},
article_location = {Albany},
article_number = {April 2023},
doi = {http://dx.doi.org/10.2147/COPD.S410372},
keywords = {GOLD classification; COPD; mortality; prognosis},
language = {eng},
issn = {1178-2005},
journal = {International Journal of chronic obstructive pulmonary disease},
title = {Prognostic Properties of the GOLD 2023 Classification System},
url = {https://www.dovepress.com/prognostic-properties-of-the-gold-2023-classification-system-peer-reviewed-fulltext-article-COPD},
volume = {18},
year = {2023}
}
TY - JOUR
ID - 2281377
AU - Brat, Kristián - Svoboda, Michal - Zatloukal, Jaromir - Plutinský, Marek - Volakova, Eva - Popelkova, Patrice - Novotna, Barbora - Dvorak, Tomas - Koblizek, Vladimir
PY - 2023
TI - Prognostic Properties of the GOLD 2023 Classification System
JF - International Journal of chronic obstructive pulmonary disease
VL - 18
IS - April 2023
SP - 661-667
EP - 661-667
PB - Dove Medical Press Ltd.
SN - 11782005
KW - GOLD classification
KW - COPD
KW - mortality
KW - prognosis
UR - https://www.dovepress.com/prognostic-properties-of-the-gold-2023-classification-system-peer-reviewed-fulltext-article-COPD
N2 - Introduction: Recently, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) has published an update on the Global Strategy for Prevention, Diagnosis and Management of COPD, introducing a new classification of chronic obstructive pulmonary disease (COPD). Our aim was to assess the prognostic value of the new GOLD classification system in comparison with the previous GOLD classification systems (GOLD stages I-IV and GOLD groups A-D) and the BODE index.Methods: We used the data of 784 patients with COPD from the Czech Multicenter Research Database of COPD. Patient survival was analyzed with the use of Kaplan-Meier estimate and Cox model of proportional risks. ROC analysis and area under curve (AUC) were used for comparison of GOLD classifications and BODE index. The analyses were performed with the use of software R (version 4.2.0).Results: We analyzed data of 782 patients with complete data on GOLD classifications. The study population comprised 72.9% of men, 89.1% current or former smokers, with a mean age of 66.6 years, a mean BMI of 27.4 and a mean FEV1 44.9% of predicted. Probability of 5-year survival differed by GOLD classification. Application of the 2023 GOLD classification showed increased risk of death in group B (HR 1.82, 95% CI 1.14-2.92; p = 0.013) and in group E (HR 2.48, 95% CI 1.54-3.99; p<0.001). The ROC analysis showed that the overall prognostic value of the 2023 GOLD classification was similarly weak to previous A-D GOLD classification schemes (AUCs 0.557-0.576) and was lower compared to the GOLD 1-4 system (AUC 0.614) and even lower when compared to the BODE index (AUC 0.715).Conclusion: We concluded that the new GOLD classification system has poor prognostic properties and that specific prediction tools (eg, the BODE index) should be used for mortality risk assessment.
ER -
BRAT, Kristián, Michal SVOBODA, Jaromir ZATLOUKAL, Marek PLUTINSKÝ, Eva VOLAKOVA, Patrice POPELKOVA, Barbora NOVOTNA, Tomas DVORAK and Vladimir KOBLIZEK. Prognostic Properties of the GOLD 2023 Classification System. \textit{International Journal of chronic obstructive pulmonary disease}. Albany: Dove Medical Press Ltd., 2023, vol.~18, April 2023, p.~661-667. ISSN~1178-2005. Available from: https://dx.doi.org/10.2147/COPD.S410372.
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