CARNA, Maria, Jan S. NOVOTNY, Neda DRAGISIC, Hanus SLAVIK, Kateřina SHEARDOVÁ, Yonas E. GEDA, Martin VYHNALEK, Jan LACZO, Jakub HORT, Zixu MAO, Robert A. RISSMAN, Marian HAJDUCH, Eric B. DAMMER and Gorazd B. STOKIN. Missorting of plasma miRNAs in aging and Alzheimer's disease. Journal of Neurochemistry. Hoboken: Wiley-Blackwell, 2023, vol. 165, No 2, p. 149-161. ISSN 0022-3042. Available from: https://dx.doi.org/10.1111/jnc.15801. |
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@article{2281517, author = {Carna, Maria and Novotny, Jan S. and Dragisic, Neda and Slavik, Hanus and Sheardová, Kateřina and Geda, Yonas E. and Vyhnalek, Martin and Laczo, Jan and Hort, Jakub and Mao, Zixu and Rissman, Robert A. and Hajduch, Marian and Dammer, Eric B. and Stokin, Gorazd B.}, article_location = {Hoboken}, article_number = {2}, doi = {http://dx.doi.org/10.1111/jnc.15801}, keywords = {aging; Alzheimer's disease; endosomes; extracellular vesicles; miRNA; ncRNA; plasma; short sequence motifs}, language = {eng}, issn = {0022-3042}, journal = {Journal of Neurochemistry}, title = {Missorting of plasma miRNAs in aging and Alzheimer's disease}, url = {https://onlinelibrary.wiley.com/doi/10.1111/jnc.15801}, volume = {165}, year = {2023} }
TY - JOUR ID - 2281517 AU - Carna, Maria - Novotny, Jan S. - Dragisic, Neda - Slavik, Hanus - Sheardová, Kateřina - Geda, Yonas E. - Vyhnalek, Martin - Laczo, Jan - Hort, Jakub - Mao, Zixu - Rissman, Robert A. - Hajduch, Marian - Dammer, Eric B. - Stokin, Gorazd B. PY - 2023 TI - Missorting of plasma miRNAs in aging and Alzheimer's disease JF - Journal of Neurochemistry VL - 165 IS - 2 SP - 149-161 EP - 149-161 PB - Wiley-Blackwell SN - 00223042 KW - aging KW - Alzheimer's disease KW - endosomes KW - extracellular vesicles KW - miRNA KW - ncRNA KW - plasma KW - short sequence motifs UR - https://onlinelibrary.wiley.com/doi/10.1111/jnc.15801 N2 - The observation that aging is regulated by microRNAs (miRNA) and at the same time represents the greatest risk factor for Alzheimer's disease (AD), prompted us to examine the circulating miRNA network in AD beyond aging. We here show that plasma miRNAs in aging are downregulated and predicted to be preferentially targeted to the extracellular vesicle (EV) content. In AD, miRNAs are further downregulated, display altered proportions of motifs relevant to their loading into EVs and secretion propensity, and are forecast to be found exclusively in EVs. The circulating miRNA network in AD, therefore, reflects pathological exacerbation of the aging process whereby physiological suppression of AD pathology by miRNAs becomes insufficient. ER -
CARNA, Maria, Jan S. NOVOTNY, Neda DRAGISIC, Hanus SLAVIK, Kateřina SHEARDOVÁ, Yonas E. GEDA, Martin VYHNALEK, Jan LACZO, Jakub HORT, Zixu MAO, Robert A. RISSMAN, Marian HAJDUCH, Eric B. DAMMER and Gorazd B. STOKIN. Missorting of plasma miRNAs in aging and Alzheimer's disease. \textit{Journal of Neurochemistry}. Hoboken: Wiley-Blackwell, 2023, vol.~165, No~2, p.~149-161. ISSN~0022-3042. Available from: https://dx.doi.org/10.1111/jnc.15801.
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