| CARNA, Maria, Jan S. NOVOTNY, Neda DRAGISIC, Hanus SLAVIK, Kateřina SHEARDOVÁ, Yonas E. GEDA, Martin VYHNALEK, Jan LACZO, Jakub HORT, Zixu MAO, Robert A. RISSMAN, Marian HAJDUCH, Eric B. DAMMER and Gorazd B. STOKIN. Missorting of plasma miRNAs in aging and Alzheimer's disease. Journal of Neurochemistry. Hoboken: Wiley-Blackwell, 2023, vol. 165, No 2, p. 149-161. ISSN 0022-3042. Available from: https://dx.doi.org/10.1111/jnc.15801. |
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@article{2281517,
author = {Carna, Maria and Novotny, Jan S. and Dragisic, Neda and Slavik, Hanus and Sheardová, Kateřina and Geda, Yonas E. and Vyhnalek, Martin and Laczo, Jan and Hort, Jakub and Mao, Zixu and Rissman, Robert A. and Hajduch, Marian and Dammer, Eric B. and Stokin, Gorazd B.},
article_location = {Hoboken},
article_number = {2},
doi = {http://dx.doi.org/10.1111/jnc.15801},
keywords = {aging; Alzheimer's disease; endosomes; extracellular vesicles; miRNA; ncRNA; plasma; short sequence motifs},
language = {eng},
issn = {0022-3042},
journal = {Journal of Neurochemistry},
title = {Missorting of plasma miRNAs in aging and Alzheimer's disease},
url = {https://onlinelibrary.wiley.com/doi/10.1111/jnc.15801},
volume = {165},
year = {2023}
}
TY - JOUR
ID - 2281517
AU - Carna, Maria - Novotny, Jan S. - Dragisic, Neda - Slavik, Hanus - Sheardová, Kateřina - Geda, Yonas E. - Vyhnalek, Martin - Laczo, Jan - Hort, Jakub - Mao, Zixu - Rissman, Robert A. - Hajduch, Marian - Dammer, Eric B. - Stokin, Gorazd B.
PY - 2023
TI - Missorting of plasma miRNAs in aging and Alzheimer's disease
JF - Journal of Neurochemistry
VL - 165
IS - 2
SP - 149-161
EP - 149-161
PB - Wiley-Blackwell
SN - 00223042
KW - aging
KW - Alzheimer's disease
KW - endosomes
KW - extracellular vesicles
KW - miRNA
KW - ncRNA
KW - plasma
KW - short sequence motifs
UR - https://onlinelibrary.wiley.com/doi/10.1111/jnc.15801
N2 - The observation that aging is regulated by microRNAs (miRNA) and at the same time represents the greatest risk factor for Alzheimer's disease (AD), prompted us to examine the circulating miRNA network in AD beyond aging. We here show that plasma miRNAs in aging are downregulated and predicted to be preferentially targeted to the extracellular vesicle (EV) content. In AD, miRNAs are further downregulated, display altered proportions of motifs relevant to their loading into EVs and secretion propensity, and are forecast to be found exclusively in EVs. The circulating miRNA network in AD, therefore, reflects pathological exacerbation of the aging process whereby physiological suppression of AD pathology by miRNAs becomes insufficient.
ER -
CARNA, Maria, Jan S. NOVOTNY, Neda DRAGISIC, Hanus SLAVIK, Kateřina SHEARDOVÁ, Yonas E. GEDA, Martin VYHNALEK, Jan LACZO, Jakub HORT, Zixu MAO, Robert A. RISSMAN, Marian HAJDUCH, Eric B. DAMMER and Gorazd B. STOKIN. Missorting of plasma miRNAs in aging and Alzheimer's disease. \textit{Journal of Neurochemistry}. Hoboken: Wiley-Blackwell, 2023, vol.~165, No~2, p.~149-161. ISSN~0022-3042. Available from: https://dx.doi.org/10.1111/jnc.15801.
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