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@proceedings{2281657,
author = {Goněc, Tomáš and Vráblová, Lucia and Pindjaková, Dominika and Strhársky, Tomáš and Oravec, Michal and Jampílek, Josef},
booktitle = {The 26th International Electronic Conference on Synthetic Organic Chemistry (ECSOC-26)},
doi = {http://dx.doi.org/10.3390/ecsoc-26-13548},
keywords = {hydroxyquinoline-carboxanilides; synthesis; lipophilicity},
language = {eng},
title = {Preparation and hydro-lipophilic properties of monosubstituted N-aryl-4-hydroxyquinoline-3-carboxanilides.},
url = {https://doi.org/10.3390/ecsoc-26-13548},
year = {2022}
}
TY - CONF
ID - 2281657
AU - Goněc, Tomáš - Vráblová, Lucia - Pindjaková, Dominika - Strhársky, Tomáš - Oravec, Michal - Jampílek, Josef
PY - 2022
TI - Preparation and hydro-lipophilic properties of monosubstituted N-aryl-4-hydroxyquinoline-3-carboxanilides.
KW - hydroxyquinoline-carboxanilides
KW - synthesis
KW - lipophilicity
UR - https://doi.org/10.3390/ecsoc-26-13548
N2 - A series of twenty-two monosubstituted N-aryl-4-hydroxyquinoline-3-carboxanilides designed as dual anti-invasive agents was prepared and characterized. Lipophilicity significantly affects biological activities of compounds and ADME properties; therefore, the lipo-hydrophilic properties of these 4-hydroxyquinoline-3-carboxanilides were investigated. All the derivatives were analyzed using reversed-phase high-performance liquid chromatography. The procedure was carried out under isocratic conditions with methanol as the organic modifier in the mobile phase using an end-capped non-polar C18 stationary reversed-phase column. In this study, correlations between the logarithm of the capacity factor k and log P/Clog P values calculated using various methods are discussed, as well as the relationships between lipophilicity and chemical structure of the studied compounds.
ER -
GONĚC, Tomáš, Lucia VRÁBLOVÁ, Dominika PINDJAKOVÁ, Tomáš STRHÁRSKY, Michal ORAVEC and Josef JAMPÍLEK. Preparation and hydro-lipophilic properties of monosubstituted N-aryl-4-hydroxyquinoline-3-carboxanilides. In \textit{The 26th International Electronic Conference on Synthetic Organic Chemistry (ECSOC-26)}. 2022. Available from: https://dx.doi.org/10.3390/ecsoc-26-13548.
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