Investigation of Novel Halogenated Cinnamanilides

JAMPÍLEK, Josef, Jiří KOS, Tomáš STRHÁRSKY, Dominika PINDJAKOVÁ, Lucia VRÁBLOVÁ, Timotej JANKECH, Tomáš GONĚC and Alois ČÍŽEK. Investigation of Novel Halogenated Cinnamanilides. In The 11th International Conference on Biomedical Engineering and Biotechnology (ICBEB 2022). 2022.

Basic information

• Original name: Investigation of Novel Halogenated Cinnamanilides
• Name in Czech: Hodnocení nových halogenovaných anlidů kyseliny skořicové.
• Authors: JAMPÍLEK, Josef, Jiří KOS, Tomáš STRHÁRSKY, Dominika PINDJAKOVÁ, Lucia VRÁBLOVÁ, Timotej JANKECH, Tomáš GONĚC and Alois ČÍŽEK.
• Edition: The 11th International Conference on Biomedical Engineering and Biotechnology (ICBEB 2022), 2022.

Other information

• Type of outcome: Conference abstract
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Organization unit: Faculty of Pharmacy
• Keywords (in Czech): léčiva typu multi-target; racionální design; deriváty kyseliny skořicové
• Keywords in English: Multi-Target Compounds; Rational Design; Cinnamic Acid Derivatives
• Tags: International impact

Abstract

One of the basic strategies in the search for new bioactive agents is inspiration from natural compounds such as cinnamic acid. It is an aromatic acid with a long history of use as an additive in plant fragrances and spices. Its derivatives are important promising substances with great potential in the search for new pharmacologically active agents. Cinnamic acid and its derivatives have attracted the attention of scientists in recent decades due to low toxicity and a wide range of biological activities such as antibacterial, antiviral, anti-inflammatory, cytotoxic, antidiabetic, hepatoprotective, antioxidant, neuroprotective, anxiolytic, and antituberculotic. Recent studies investigating the antimicrobial activities of an extensive series of variously substituted cinnamic anilides have revealed compounds with promising anti-infective potential. Since the introduction of a halogen into the molecule structure is known to increase the anti-invasive activity, new halogenated series of anilides were designed and their properties are discussed in this contribution.