INVESTIGATIONS OF NEW DERIVATIVES OF β-HYDROXYARYLCARBOXYLIC ACIDS

JAMPÍLEK, Josef, Dominika PINDJAKOVÁ, Tomáš GONĚC, Jiří KOS, Aleš IMRAMOVSKÝ and Alois ČÍŽEK. INVESTIGATIONS OF NEW DERIVATIVES OF β-HYDROXYARYLCARBOXYLIC ACIDS. In 12TH JMMC – JOINT MEETING ON MEDICINAL CHEMISTRY. 2022. ISBN 978-80-969474-9-2.

Basic information

Original name

INVESTIGATIONS OF NEW DERIVATIVES OF β-HYDROXYARYLCARBOXYLIC ACIDS

Name in Czech

Hodnocení nových derivátů β-hydroxyarylkarboxylových kyselin

Authors

JAMPÍLEK, Josef, Dominika PINDJAKOVÁ, Tomáš GONĚC, Jiří KOS, Aleš IMRAMOVSKÝ and Alois ČÍŽEK

Edition

12TH JMMC – JOINT MEETING ON MEDICINAL CHEMISTRY, 2022

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Other information

Type of outcome

Prezentace na konferencích

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

ISBN

978-80-969474-9-2

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Abstract

V originále

One possibility for the design of new drugs is inspiration from natural compounds5 with multiple activities,6 for example, cinnamic or salicylic acid derivatives. By modifying the scaffolds of such compounds, molecules with a wide spectrum of action can be obtained, and thus it is advantageous to use them for the design of multi-target anti-invasive agents. Recently, new anilides structurally derived from hydroxyarylcarboxylic acids and their carbamates have been designed, which showed strong bactericidal activity against drug-resistant clinical isolates of Gram-positive bacteria as well as activity against mycobacteria. These small molecules will be discussed within this contribution.