KOMOROVÁ, Zuzana, Jan MÁCHAL, Ladislav GROCH, Lenka ŠPINAROVÁ and Karel LÁBR. Effect of selected cardiovascular factors on mortality in patients with ST-segment elevation myocardial infarction treated with primary coronary intervention. BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY. BRATISLAVA: AEPRESS SRO, 2023, vol. 124, No 6, p. 421-426. ISSN 0006-9248. Available from: https://dx.doi.org/10.4149/BLL_2023_064.
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Basic information
Original name Effect of selected cardiovascular factors on mortality in patients with ST-segment elevation myocardial infarction treated with primary coronary intervention.
Authors KOMOROVÁ, Zuzana (703 Slovakia, belonging to the institution), Jan MÁCHAL (203 Czech Republic, belonging to the institution), Ladislav GROCH (203 Czech Republic, belonging to the institution), Lenka ŠPINAROVÁ (203 Czech Republic, belonging to the institution) and Karel LÁBR (203 Czech Republic, guarantor, belonging to the institution).
Edition BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, BRATISLAVA, AEPRESS SRO, 2023, 0006-9248.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30201 Cardiac and Cardiovascular systems
Country of publisher Slovakia
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 1.500 in 2022
RIV identification code RIV/00216224:14110/23:00130763
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.4149/BLL_2023_064
UT WoS 000994256900003
Keywords in English myocardial infarction; pimary coronary intervention; shock; mortality; cardio-specific markers
Tags 14110115, 14110518, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 15/6/2023 13:44.
Abstract
OBJECTIVE: This work was aimed at analyzing in-hospital, 30-day and 1-year mortality rates, impact of selected cardiovascular factors on mortality of patients with ST-segment elevation myocardial infarction (STEMI) manifested on electrocardiogram (ECG) and treated by the percutaneous coronary intervention (PCI) at our cardiac center, comparing the subgroup of non-shock (survivors and deceased) patients after STEMI and evaluating how these patients differ from each other. METHODS: In total, 270 patients with STEMI manifested on ECG and treated by PCI were enrolled between April 1, 2018, and March 31, 2019, at our cardiologic center. Our study sought to determine the risk of death after acute myocardial infarction with carefully selected factors and parameters such as the presence of cardiogenic shock, ischemic time, left ventricular ejection fraction (LVEF), post-PCI TIMI (thrombolysis in myocardial infarction) flow and serum levels of cardio-specific markers, namely troponin T, creatine kinase and N-terminal pro-brain natriuretic peptide (NT-proBNP). Further evaluation included in-hospital, 30-day and 1-year mortality rates in shock and non-shock patients and determination of factors that influence the survival separately in each subgroup. The follow-up was carried out for 12 months after the myocardial infarction in form of outpatient examinations. After 12 months of follow-up, the collected data were statistically evaluated. RESULTS: Shock and non-shock patients differed in mortality and several other parameters including NT-proBNP values, ischemic time, TIMI flow defect and LVEF. In all outcomes (in-hospital, 30-day and 1-year mortality rates) the shock patients did worse than non-shock patients (p < 0.001). In addition, age, gender, LVEF, NT-proBNP and post-PCI TIMI flow less than 3 were found to be important factors influencing the overall survival. In shock patients, the survival was associated with age, LVEF and TIMI flow, while in non -shock patients, the factors predicting survival were age, LVEF, level of NT-proBNP and troponin levels. CONCLUSION: Shock patients differed in terms of mortality in post-PCI TIMI flow, while non-shock patients varied in troponin and NT-proBNP levels. Despite early intervention, certain risk factors might affect the clinical outcome and prognosis of patients with STEMI treated by PCI (Tab. 5, Fig. 1, Ref. 30).
Links
MUNI/A/1410/2022, interní kód MUName: Nové trendy v diagnostice a managementu srdečních onemocnění
Investor: Masaryk University, New trends in diagnostics and management of cardiac diseases
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