Detailed Information on Publication Record
2023
Effect of selected cardiovascular factors on mortality in patients with ST-segment elevation myocardial infarction treated with primary coronary intervention.
KOMOROVÁ, Zuzana, Jan MÁCHAL, Ladislav GROCH, Lenka ŠPINAROVÁ, Karel LÁBR et. al.Basic information
Original name
Effect of selected cardiovascular factors on mortality in patients with ST-segment elevation myocardial infarction treated with primary coronary intervention.
Authors
KOMOROVÁ, Zuzana (703 Slovakia, belonging to the institution), Jan MÁCHAL (203 Czech Republic, belonging to the institution), Ladislav GROCH (203 Czech Republic, belonging to the institution), Lenka ŠPINAROVÁ (203 Czech Republic, belonging to the institution) and Karel LÁBR (203 Czech Republic, guarantor, belonging to the institution)
Edition
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, BRATISLAVA, AEPRESS SRO, 2023, 0006-9248
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30201 Cardiac and Cardiovascular systems
Country of publisher
Slovakia
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 1.500 in 2022
RIV identification code
RIV/00216224:14110/23:00130763
Organization unit
Faculty of Medicine
UT WoS
000994256900003
Keywords in English
myocardial infarction; pimary coronary intervention; shock; mortality; cardio-specific markers
Tags
International impact, Reviewed
Změněno: 15/6/2023 13:44, Mgr. Tereza Miškechová
Abstract
V originále
OBJECTIVE: This work was aimed at analyzing in-hospital, 30-day and 1-year mortality rates, impact of selected cardiovascular factors on mortality of patients with ST-segment elevation myocardial infarction (STEMI) manifested on electrocardiogram (ECG) and treated by the percutaneous coronary intervention (PCI) at our cardiac center, comparing the subgroup of non-shock (survivors and deceased) patients after STEMI and evaluating how these patients differ from each other. METHODS: In total, 270 patients with STEMI manifested on ECG and treated by PCI were enrolled between April 1, 2018, and March 31, 2019, at our cardiologic center. Our study sought to determine the risk of death after acute myocardial infarction with carefully selected factors and parameters such as the presence of cardiogenic shock, ischemic time, left ventricular ejection fraction (LVEF), post-PCI TIMI (thrombolysis in myocardial infarction) flow and serum levels of cardio-specific markers, namely troponin T, creatine kinase and N-terminal pro-brain natriuretic peptide (NT-proBNP). Further evaluation included in-hospital, 30-day and 1-year mortality rates in shock and non-shock patients and determination of factors that influence the survival separately in each subgroup. The follow-up was carried out for 12 months after the myocardial infarction in form of outpatient examinations. After 12 months of follow-up, the collected data were statistically evaluated. RESULTS: Shock and non-shock patients differed in mortality and several other parameters including NT-proBNP values, ischemic time, TIMI flow defect and LVEF. In all outcomes (in-hospital, 30-day and 1-year mortality rates) the shock patients did worse than non-shock patients (p < 0.001). In addition, age, gender, LVEF, NT-proBNP and post-PCI TIMI flow less than 3 were found to be important factors influencing the overall survival. In shock patients, the survival was associated with age, LVEF and TIMI flow, while in non -shock patients, the factors predicting survival were age, LVEF, level of NT-proBNP and troponin levels. CONCLUSION: Shock patients differed in terms of mortality in post-PCI TIMI flow, while non-shock patients varied in troponin and NT-proBNP levels. Despite early intervention, certain risk factors might affect the clinical outcome and prognosis of patients with STEMI treated by PCI (Tab. 5, Fig. 1, Ref. 30).
Links
| MUNI/A/1410/2022, interní kód MU |
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