J 2023

Effect of titanium nanostructured surface on fibroblast behavior

VRCHOVECKÁ, Kateřina, Jan KUTA, Martin UHER, Jan PŘIBYL, Monika PÁVKOVÁ GOLDBERGOVÁ et. al.

Basic information

Original name

Effect of titanium nanostructured surface on fibroblast behavior

Authors

VRCHOVECKÁ, Kateřina (203 Czech Republic, belonging to the institution), Jan KUTA (203 Czech Republic, belonging to the institution), Martin UHER (203 Czech Republic, belonging to the institution), Jan PŘIBYL (203 Czech Republic, guarantor, belonging to the institution) and Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic, belonging to the institution)

Edition

Journal of Biomedical Materials Research Part A, HOBOKEN, WILEY111, 2023, 1549-3296

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

21002 Nano-processes ;

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.900 in 2022

RIV identification code

RIV/00216224:14110/23:00130787

Organization unit

Faculty of Medicine

DOI

UT WoS

000958302100001

Keywords in English

cell morphology; cell viability; fibroblast; ion release; titanium nanotubes

Tags

Tags

International impact, Reviewed
Změněno: 18/10/2024 13:45, Ing. Jana Kuchtová

Abstract

V originále

As the consumption of implants increases, so do the requirements for individual types of implants, for example, improved biocompatibility or longevity. Therefore, the nano-modification of the titanium surface is often chosen. The aim was to characterize the modified surface with a focus on medical applications. The titanium surface was modified by the anodic oxidation method to form nanotubes. Subsequently, the material was characterized and analyzed for medical applications—surface morphology, surface wettability, chemical composition, and release of ions into biological fluids. A human gingival fibroblasts (HGFb) cell line was used in the viability study. A homogeneous layer of nanotubes of defined dimensions was formed on the titanium surface, ensuring the material's biocompatibility—the preparation conditions influence the resulting properties of the nanostructured surface. Nanostructured titanium exhibited more suitable characteristics (e.g., wettability, roughness, ion release) for biological applications than compared to pure titanium. It was possible to understand the behavior of the modified layer on the titanium surface and its effect on cell behavior. Another contribution of this work is the combination of material characterization (ion release) with the study of cytocompatibility (direct contact of cells with metals).

Links

EF17_043/0009632, research and development project
Name: CETOCOEN Excellence
EF18_046/0015974, research and development project
Name: Modernizace České infrastruktury pro integrativní strukturní biologii
GA20-11321S, research and development project
Name: Vliv mikrostruktury a povrchových úprav na absorpci vodíku v bio-kompatibilních slitinách
Investor: Czech Science Foundation
LM2018121, research and development project
Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI
MUNI/A/1370/2022, interní kód MU
Name: Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň
Investor: Masaryk University, Pathophysiology of selected complex diseases from molecular to systemic level
NU20-08-00149, research and development project
Name: Multicentrické hodnocení hypersenzitivní reakce u pacientů indikovaných k totální náhradě kloubu včetně hodnocení důvodů reimplanace
Investor: Ministry of Health of the CR, Subprogram 1 - standard
90121, large research infrastructures
Name: RECETOX RI
90242, large research infrastructures
Name: CIISB III