The study focused on pure pig breeds and their comparison in the genotypes of the CYP2E1, TEAD3, HSD3B, and CYB5A genes associated with skatole and androstenone. The research examined four common commercial breeds (Large White, Landrace, Pietrain, Duroc) and compared them with the original Czech autochthonous Přeštice Black Pied breed, which is also classified as a gene source, with the breed being highlighted for its meat quality. The research shows that there are differences between purebred individuals. Due to breeding programs, genotyping of breeding boars and sows is not only possible but also relevant.