a 2023

SEMISOLID HYDROPHILIC DRUG FORMS FOR LOCAL APPLICATION OF PSEUDOMONAS AERUGINOSA BACTERIOPHAGES

KOMÁRKOVÁ, Marie, Martin BENEŠÍK, Tereza ŠOPÍKOVÁ, Kateřina PLACHÁ, Filip RŮŽIČKA et. al.

Basic information

Original name

SEMISOLID HYDROPHILIC DRUG FORMS FOR LOCAL APPLICATION OF PSEUDOMONAS AERUGINOSA BACTERIOPHAGES

Name in Czech

Polotuhé lékové formy pro lokální aplikaci bakteriofágů Pseudomonas aeruginosa

Name (in English)

SEMISOLID HYDROPHILIC DRUG FORMS FOR LOCAL APPLICATION OF PSEUDOMONAS AERUGINOSA BACTERIOPHAGES

Authors

KOMÁRKOVÁ, Marie, Martin BENEŠÍK, Tereza ŠOPÍKOVÁ, Kateřina PLACHÁ, Filip RŮŽIČKA and Roman PANTŮČEK

Edition

Targeting Phage Therapy 2023 World Congress, 2023

Other information

Language

Czech

Type of outcome

Konferenční abstrakt

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Organization unit

Faculty of Science

Keywords (in Czech)

bakteriofágy, Pseudomonas, hydrogel, mast, stabilita fága

Keywords in English

bacteriophages, Pseudomonas, hydrogel, ointment, phage stability
Změněno: 15/6/2023 11:52, Mgr. Marie Komárková

Abstract

V originále

We focused on three phages with variant morphology i.e., myovirus PA1, siphovirus PA10, and podovirus LUZ19. Every phage was mixed with carbomer gel and macrogol ointment. Their stabilities were assessed by drop test with the sensitive pseudomonal strains for five weeks. In the macrogol ointment, the myovirus PA1 has the highest titer decrease (i.e., four orders), in contrast with carbomer gel, when the most significant titer reduction was in the case of siphovirus PA10 (i.e., two orders). Generally, the phage stability in macrogol ointment was worse than in carbomer gel. This difference was probably caused by variant features of these drug forms, especially viscosity and antimicrobial effect. This study pointed out essential facts about the formulation and assessment of semisolid drug forms containing pseudomonal bacteriophages for the therapy of wound infections.

Links

LX22NPO5103, research and development project
Name: Národní institut virologie a bakteriologie (Acronym: NIVB)
Investor: Ministry of Education, Youth and Sports of the CR, National Institute of Virology and Bacteriology, 5.1 EXCELES