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@proceedings{2291600,
author = {Komárková, Marie and Benešík, Martin and Šopíková, Tereza and Plachá, Kateřina and Růžička, Filip and Pantůček, Roman},
booktitle = {Targeting Phage Therapy 2023 World Congress},
keywords = {bacteriophages, Pseudomonas, hydrogel, ointment, phage stability},
language = {cze},
title = {SEMISOLID HYDROPHILIC DRUG FORMS FOR LOCAL APPLICATION OF PSEUDOMONAS AERUGINOSA BACTERIOPHAGES},
url = {https://phagetherapy-site.com/},
year = {2023}
}
TY - CONF
ID - 2291600
AU - Komárková, Marie - Benešík, Martin - Šopíková, Tereza - Plachá, Kateřina - Růžička, Filip - Pantůček, Roman
PY - 2023
TI - SEMISOLID HYDROPHILIC DRUG FORMS FOR LOCAL APPLICATION OF PSEUDOMONAS AERUGINOSA BACTERIOPHAGES
KW - bacteriophages, Pseudomonas, hydrogel, ointment, phage stability
UR - https://phagetherapy-site.com/
N2 - We focused on three phages with variant morphology i.e., myovirus PA1, siphovirus PA10, and podovirus LUZ19. Every phage was mixed with carbomer gel and macrogol ointment. Their stabilities were assessed by drop test with the sensitive pseudomonal strains for five weeks. In the macrogol ointment, the myovirus PA1 has the highest titer decrease (i.e., four orders), in contrast with carbomer gel, when the most significant titer reduction was in the case of siphovirus PA10 (i.e., two orders). Generally, the phage stability in macrogol ointment was worse than in carbomer gel. This difference was probably caused by variant features of these drug forms, especially viscosity and antimicrobial effect. This study pointed out essential facts about the formulation and assessment of semisolid drug forms containing pseudomonal bacteriophages for the therapy of wound infections.
ER -
KOMÁRKOVÁ, Marie, Martin BENEŠÍK, Tereza ŠOPÍKOVÁ, Kateřina PLACHÁ, Filip RŮŽIČKA and Roman PANTŮČEK. SEMISOLID HYDROPHILIC DRUG FORMS FOR LOCAL APPLICATION OF PSEUDOMONAS AERUGINOSA BACTERIOPHAGES. In \textit{Targeting Phage Therapy 2023 World Congress}. 2023.
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