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@article{2291628,
author = {Hlaváčková, Eva and Křenová, Zdenka and Kerekes, Arpád and Slanina, Peter and Vlková, Marcela},
article_location = {Olomouc},
article_number = {2},
doi = {http://dx.doi.org/10.5507/bp.2023.021},
keywords = {rituximab; B non-Hodgkin lymphoma; chemotherapy; late complications of chemotherapy; hypogammaglobulinemia; children and adolescents},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers, Olomouc: Palacky University},
title = {B cell subsets reconstitution and immunoglobulin levels in children and adolescents with B non-Hodgkin lymphoma after treatment with single anti CD20 agent dose included in chemotherapeutic protocols: single center and review of the literature},
url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3334},
volume = {168},
year = {2024}
}
TY - JOUR
ID - 2291628
AU - Hlaváčková, Eva - Křenová, Zdenka - Kerekes, Arpád - Slanina, Peter - Vlková, Marcela
PY - 2024
TI - B cell subsets reconstitution and immunoglobulin levels in children and adolescents with B non-Hodgkin lymphoma after treatment with single anti CD20 agent dose included in chemotherapeutic protocols: single center and review of the literature
JF - Biomedical Papers, Olomouc: Palacky University
VL - 168
IS - 2
SP - 167-176
EP - 167-176
PB - Palacky University
SN - 12138118
KW - rituximab
KW - B non-Hodgkin lymphoma
KW - chemotherapy
KW - late complications of chemotherapy
KW - hypogammaglobulinemia
KW - children and adolescents
UR - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3334
N2 - Background. RTX, an anti-CD20 monoclonal antibody, added to chemotherapy has proven to be effective in children and adolescents with high-grade, high-risk and matured non-Hodgk in lymphoma. RTX leads to prompt CD19+ B lymphocyte depletion. However, despite preserved immunoglobulin production by long-lived plasmablasts after treatment, patients remain at risk of prolonged hypogammaglobulinemia. Further, there are few general guidelines for immunology laboratories and clinical feature monitoring after B cell-targeted therapies. The aim of this paper is to describe B cell reconstitution and immunoglobulin levels after pediatric B-NHL protocols, that included a single RTX dose and to review the literature. Methods. A retrospective single-center study on the impact of a single RTX dose included in a chemotherapeutic pediatric B Non-Hodgkin Lymphoma (B-NHL) treatment protocols. Immunology laboratory and clinical features were evaluated over an eight hundred days follow-up (FU) period, after completing B-NHL treatment. Results. Nineteen patients (fifteen Burkitt lymphoma, three Diffuse large B cell lymphoma, and one Marginal zone B cell lymphoma) fulfilled the inclusion criteria. Initiation of B cell subset reconstitution occurred a median of three months after B-NHL treatment. Naive and transitional B cells declined over the FU in contrast to the marginal zone and the switched memory B cell increase. The percentage of patients with IgG, IgA, and IgM hypogammaglobulinemia declined consistently over the FU. Prolonged IgG hypogammaglobulinemia was detectable in 9%, IgM in 13%, and IgA in 25%. All revaccinated patients responded to protein-based vaccines by specific IgG antibody production increase. Following antibiotic prophylaxes, none of the patients with hypogammaglobulinemia manifested with either a severe or opportunistic infection course. Conclusion. The addition of a single RTX dose to the chemotherapeutic treatment protocols was not shown to increase the risk of developing secondary antibody deficiency in B-NHL pediatric patients. Observed prolonged hypogammaglobulinemia remained clinically silent. However interdisciplinary agreement on regular long-term immunology FU after anti-CD20 agent treatment is required.
ER -
HLAVÁČKOVÁ, Eva, Zdenka KŘENOVÁ, Arpád KEREKES, Peter SLANINA and Marcela VLKOVÁ. B cell subsets reconstitution and immunoglobulin levels in children and adolescents with B non-Hodgkin lymphoma after treatment with single anti CD20 agent dose included in chemotherapeutic protocols: single center and review of the literature. \textit{Biomedical Papers, Olomouc: Palacky University}. Olomouc: Palacky University, 2024, vol.~168, No~2, p.~167-176. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2023.021.
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