| BRAT, Kristián, Pavel HOMOLKA, Zdeněk MERTA, Miloš CHOBOLA, Michaela HEROUTOVA, Monika BRATOVÁ, Ladislav MITÁŠ, Zdeněk CHOVANEC, Teodor HORVÁTH, Michal BENEJ, Jaroslav IVIČIČ, Michal SVOBODA, Vladimír ŠRÁMEK, Lyle J OLSON and Ivan ČUNDRLE. Prediction of Postoperative Complications: Ventilatory Efficiency and Rest End-tidal Carbon Dioxide. Annals of Thoracic Surgery. New York: Elsevier Science Inc., 2023, vol. 115, No 5, p. 1305-1311. ISSN 0003-4975. Available from: https://dx.doi.org/10.1016/j.athoracsur.2021.11.073. |
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@article{2292750,
author = {Brat, Kristián and Homolka, Pavel and Merta, Zdeněk and Chobola, Miloš and Heroutova, Michaela and Bratová, Monika and Mitáš, Ladislav and Chovanec, Zdeněk and Horváth, Teodor and Benej, Michal and Ivičič, Jaroslav and Svoboda, Michal and Šrámek, Vladimír and Olson, Lyle J and Čundrle, Ivan},
article_location = {New York},
article_number = {5},
doi = {http://dx.doi.org/10.1016/j.athoracsur.2021.11.073},
keywords = {Postoperative Complications; Prediction; Ventilatory Efficiency; Rest End-tidal Carbon Dioxide},
language = {eng},
issn = {0003-4975},
journal = {Annals of Thoracic Surgery},
title = {Prediction of Postoperative Complications: Ventilatory Efficiency and Rest End-tidal Carbon Dioxide},
url = {https://www.sciencedirect.com/science/article/pii/S0003497522000601},
volume = {115},
year = {2023}
}
TY - JOUR
ID - 2292750
AU - Brat, Kristián - Homolka, Pavel - Merta, Zdeněk - Chobola, Miloš - Heroutova, Michaela - Bratová, Monika - Mitáš, Ladislav - Chovanec, Zdeněk - Horváth, Teodor - Benej, Michal - Ivičič, Jaroslav - Svoboda, Michal - Šrámek, Vladimír - Olson, Lyle J - Čundrle, Ivan
PY - 2023
TI - Prediction of Postoperative Complications: Ventilatory Efficiency and Rest End-tidal Carbon Dioxide
JF - Annals of Thoracic Surgery
VL - 115
IS - 5
SP - 1305-1311
EP - 1305-1311
PB - Elsevier Science Inc.
SN - 00034975
KW - Postoperative Complications
KW - Prediction
KW - Ventilatory Efficiency
KW - Rest End-tidal Carbon Dioxide
UR - https://www.sciencedirect.com/science/article/pii/S0003497522000601
N2 - BACKGROUND Cardiopulmonary exercise testing parameters including ventilatory efficiency (VE/VCO2 slope) are used for risk assessment of lung resection candidates. However, many patients are unable or unwilling to undergo exercise. VE/VCO2 slope is closely related to the partial pressure of end-tidal carbon dioxide (PETCO2). We hypothesized PETCO2 at rest predicts postoperative pulmonary complications.METHODS Consecutive lung resection candidates were included in this prospective multicenter study. Postoperative respiratory complications were assessed from the first 30 postoperative days or from the hospital stay. Student t test or Mann-Whitney U test was used for comparison. Multivariate stepwise logistic regression analysis was used to analyze association with the development of postoperative pulmonary complications. The De Long test was used to compare area under the curve (AUC). Data are summarized as median (interquartile range).RESULTS Three hundred fifty-three patients were analyzed, of which 59 (17%) developed postoperative pulmonary complications. PETCO2 at rest was significantly lower (27 [24-30] vs 29 [26-32] mm Hg; P < .01) and VE/VCO2 slope during exercise significantly higher (35 [30-40] vs 29 [25-33]; P < .01) in patients who developed postoperative pulmonary complications. Both rest PETCO2 with odds ratio 0.90 (95% confidence interval [CI] 0.83-0.97); P = .01 and VE/VCO2 slope with odds ratio 1.10 (95% CI 1.05-1.16); P < .01 were independently associated with postoperative pulmonary complications by multivariate stepwise logistic regression analysis. There was no significant difference between AUC of both models (rest PETCO2: AUC = 0.79 (95% CI 0.74-0.85); VE/VCO2 slope: AUC = 0.81 (95% CI 0.75-0.86); P = .48).CONCLUSIONS PETCO2 at rest has similar prognostic utility as VE/VCO2 slope, suggesting rest PETCO2 may be used for postoperative pulmonary complications prediction in lung resection candidates.
ER -
BRAT, Kristián, Pavel HOMOLKA, Zdeněk MERTA, Miloš CHOBOLA, Michaela HEROUTOVA, Monika BRATOVÁ, Ladislav MITÁŠ, Zdeněk CHOVANEC, Teodor HORVÁTH, Michal BENEJ, Jaroslav IVIČIČ, Michal SVOBODA, Vladimír ŠRÁMEK, Lyle J OLSON and Ivan ČUNDRLE. Prediction of Postoperative Complications: Ventilatory Efficiency and Rest End-tidal Carbon Dioxide. \textit{Annals of Thoracic Surgery}. New York: Elsevier Science Inc., 2023, vol.~115, No~5, p.~1305-1311. ISSN~0003-4975. Available from: https://dx.doi.org/10.1016/j.athoracsur.2021.11.073.
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