SVOBODA, Martin, Jana BLAHOVA, Jiří JARKOVSKÝ, Adam ZACHARDA, Suzana HAJKOVA, Jonas VANHARA and Jan VASEK. Efficacy of the intranasal application of azaperone for sedation in weaned piglets. Veterinarni Medicina. Praha: Czech Academy of Agricultural Sciences, 2023, vol. 68, No 4, p. 145-151. ISSN 0375-8427. Available from: https://dx.doi.org/10.17221/21/2023-VETMED.
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Basic information
Original name Efficacy of the intranasal application of azaperone for sedation in weaned piglets
Authors SVOBODA, Martin (203 Czech Republic, guarantor), Jana BLAHOVA (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Adam ZACHARDA (203 Czech Republic), Suzana HAJKOVA (203 Czech Republic), Jonas VANHARA (203 Czech Republic) and Jan VASEK (203 Czech Republic).
Edition Veterinarni Medicina, Praha, Czech Academy of Agricultural Sciences, 2023, 0375-8427.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 40301 Veterinary science
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 0.700 in 2022
RIV identification code RIV/00216224:14110/23:00131023
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.17221/21/2023-VETMED
UT WoS 000981543900001
Keywords in English behaviour; neuroleptic; pharmacodynamics; swine
Tags 14119612, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 21/6/2023 09:12.
Abstract
The aim of the study was to compare the efficacy of the intranasal and parenteral administration of azaperone in order to achieve pig sedation. A total of 32 weaned piglets divided into 4 groups (8 piglets in each group) were used. Group A was injected intramuscularly (i.m.) with azaperone (Stresnil (R), 40 mg/ml inj.; Elanco Animal Health) at a dose of 2 mg/kg of body weight (b.w.). Group B received a dose of 2 mg/kg b.w. of azaperone intranasally. Group C was given azaperone intranasally at a dose of 4 mg/kg b.w. Group D was given 1 ml of saline intranasally and served as the control group. The response to the defined stimulus (a blunt blow of a metal rod into a metal edge of a pen), the degree of salivation, movement level, body temperature and serum azaperone concentration were included in the trial. We found that in order to induce an adequate level of sedation comparable to the standard method of application, i.e., 2 mg/kg b.w. i.m., the intranasal administration of azaperone at a dose of 4 mg/kg body weight is required.
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