Efficacy of the intranasal application of azaperone for
sedation in weaned piglets

J 2023

Efficacy of the intranasal application of azaperone for sedation in weaned piglets

SVOBODA, Martin, Jana BLAHOVA, Jiří JARKOVSKÝ, Adam ZACHARDA, Suzana HAJKOVA et. al.

Basic information

Original name

Efficacy of the intranasal application of azaperone for sedation in weaned piglets

Authors

SVOBODA, Martin (203 Czech Republic, guarantor), Jana BLAHOVA (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Adam ZACHARDA (203 Czech Republic), Suzana HAJKOVA (203 Czech Republic), Jonas VANHARA (203 Czech Republic) and Jan VASEK (203 Czech Republic)

Edition

Veterinarni Medicina, Praha, Czech Academy of Agricultural Sciences, 2023, 0375-8427

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

40301 Veterinary science

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 0.700 in 2022

RIV identification code

RIV/00216224:14110/23:00131023

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.17221/21/2023-VETMED

UT WoS

000981543900001

Keywords in English

behaviour; neuroleptic; pharmacodynamics; swine

Abstract

V originále

The aim of the study was to compare the efficacy of the intranasal and parenteral administration of azaperone in order to achieve pig sedation. A total of 32 weaned piglets divided into 4 groups (8 piglets in each group) were used. Group A was injected intramuscularly (i.m.) with azaperone (Stresnil (R), 40 mg/ml inj.; Elanco Animal Health) at a dose of 2 mg/kg of body weight (b.w.). Group B received a dose of 2 mg/kg b.w. of azaperone intranasally. Group C was given azaperone intranasally at a dose of 4 mg/kg b.w. Group D was given 1 ml of saline intranasally and served as the control group. The response to the defined stimulus (a blunt blow of a metal rod into a metal edge of a pen), the degree of salivation, movement level, body temperature and serum azaperone concentration were included in the trial. We found that in order to induce an adequate level of sedation comparable to the standard method of application, i.e., 2 mg/kg b.w. i.m., the intranasal administration of azaperone at a dose of 4 mg/kg body weight is required.

Citovat

SVOBODA, Martin, Jana BLAHOVA, Jiří JARKOVSKÝ, Adam ZACHARDA, Suzana HAJKOVA, Jonas VANHARA and Jan VASEK. Efficacy of the intranasal application of azaperone for sedation in weaned piglets. Veterinarni Medicina. Praha: Czech Academy of Agricultural Sciences, 2023, vol. 68, No 4, p. 145-151. ISSN 0375-8427. Available from: https://dx.doi.org/10.17221/21/2023-VETMED.

@article{2292981,
   author = {Svoboda, Martin and Blahova, Jana and Jarkovský, Jiří and Zacharda, Adam and Hajkova, Suzana and Vanhara, Jonas and Vasek, Jan},
   article_location = {Praha},
   article_number = {4},
   doi = {http://dx.doi.org/10.17221/21/2023-VETMED},
   keywords = {behaviour; neuroleptic; pharmacodynamics; swine},
   language = {eng},
   issn = {0375-8427},
   journal = {Veterinarni Medicina},
   title = {Efficacy of the intranasal application of azaperone for sedation in weaned piglets},
   url = {https://vetmed.agriculturejournals.cz/artkey/vet-202304-0002_efficacy-of-the-intranasal-application-of-azaperone-for-sedation-in-weaned-piglets.php},
   volume = {68},
   year = {2023}
}

TY  - JOUR
ID  - 2292981
AU  - Svoboda, Martin - Blahova, Jana - Jarkovský, Jiří - Zacharda, Adam - Hajkova, Suzana - Vanhara, Jonas - Vasek, Jan
PY  - 2023
TI  - Efficacy of the intranasal application of azaperone for sedation in weaned piglets
JF  - Veterinarni Medicina
VL  - 68
IS  - 4
SP  - 145-151
EP  - 145-151
PB  - Czech Academy of Agricultural Sciences
SN  - 03758427
KW  - behaviour
KW  - neuroleptic
KW  - pharmacodynamics
KW  - swine
UR  - https://vetmed.agriculturejournals.cz/artkey/vet-202304-0002_efficacy-of-the-intranasal-application-of-azaperone-for-sedation-in-weaned-piglets.php
N2  - The aim of the study was to compare the efficacy of the intranasal and parenteral administration of azaperone in order to achieve pig sedation. A total of 32 weaned piglets divided into 4 groups (8 piglets in each group) were used. Group A was injected intramuscularly (i.m.) with azaperone (Stresnil (R), 40 mg/ml inj.; Elanco Animal Health) at a dose of 2 mg/kg of body weight (b.w.). Group B received a dose of 2 mg/kg b.w. of azaperone intranasally. Group C was given azaperone intranasally at a dose of 4 mg/kg b.w. Group D was given 1 ml of saline intranasally and served as the control group. The response to the defined stimulus (a blunt blow of a metal rod into a metal edge of a pen), the degree of salivation, movement level, body temperature and serum azaperone concentration were included in the trial. We found that in order to induce an adequate level of sedation comparable to the standard method of application, i.e., 2 mg/kg b.w. i.m., the intranasal administration of azaperone at a dose of 4 mg/kg body weight is required.
ER  -

SVOBODA, Martin, Jana BLAHOVA, Jiří JARKOVSKÝ, Adam ZACHARDA, Suzana HAJKOVA, Jonas VANHARA and Jan VASEK. Efficacy of the intranasal application of azaperone for sedation in weaned piglets. \textit{Veterinarni Medicina}. Praha: Czech Academy of Agricultural Sciences, 2023, vol.~68, No~4, p.~145-151. ISSN~0375-8427. Available from: https://dx.doi.org/10.17221/21/2023-VETMED.

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