Definition, diagnosis and treatment of oligometastatic
oesophagogastric cancer: A Delphi consensus study in Europe

J 2023

Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe

KROESE, Tiuri E, Hanneke W M VAN LAARHOVEN, Sebastian F SCHOPPMAN, Pieter R A J DESEYNE, Eric VAN CUTSEM et. al.

Basic information

Original name

Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe

Authors

KROESE, Tiuri E, Hanneke W M VAN LAARHOVEN, Sebastian F SCHOPPMAN, Pieter R A J DESEYNE, Eric VAN CUTSEM, Karin HAUSTERMANS, Philippe NAFTEUX, Melissa THOMAS, Radka OBERMANNOVÁ (203 Czech Republic, belonging to the institution), Hanna R MORTENSEN, Marianne NORDSMARK, Per PFEIFFER, Anneli ELME, Antoine ADENIS, Guillaume PIESSEN, Christiane J BRUNS, Florian LORDICK, Ines GOCKEL, Markus MOEHLER, Cihan GANI, Theodore LIAKAKOS, John REYNOLDS, Alessio G MORGANTI, Riccardo ROSATI, Carlo CASTORO, Francesco CELLINI, Domenico UGO, Franco ROVIELLO, Maria BENCIVENGA, Giovanni DE MANZONI, Mark I van Berge HENEGOUWEN, Maarten C C M HULSHOF, van Dieren JOLANDA, Marieke VOLLEBERGH, Johanna W VAN SANDICK, Paul JEENE, Christel T MUIJS, Marije SLINGERLAND, Francine E M VONCKEN, Henk HARTGRINK, Geert-Jan CREEMERS, Maurice J C VAN DER SANGEN, Grard NIEUWENHUIJZEN, Maaike BERBEE, Marcel VERHEIJ, Bas WIJNHOVEN, V Beerepoot LAURENS, Nadia H MOHAMMAD, Stella MOOK, Jelle P RUURDA, Piotr KOLODZIEJCZYK, Wojciech P POLKOWSKI, Lucjan WYRWICZ, Maria ALSINA, Manuel PERA, Tania F KANONNIKOFF, Andres CERVANTES, Magnus NILSSON, Stefan MONIG, Anna D WAGNER, Matthias GUCKENBERGER, Ewen A GRIFFITHS, Elizabeth SMYTH, George B HANNA, Sheraz MARKAR, M Asif CHAUDRY, Maria A HAWKINS, Edward CHEONG, Richard VAN HILLEGERSBERG and Peter S N VAN ROSSUM (guarantor)

Edition

European Journal of Cancer, Oxford, Elsevier Science Inc. 2023, 0959-8049

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 8.400 in 2022

RIV identification code

RIV/00216224:14110/23:00131024

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.ejca.2023.02.015

UT WoS

000982949200001

Keywords in English

Oesophageal cancer; Gastric cancer; Metastasis; Metastasectomy; Stereotactic body radiotherapy; Oligometastasis

Abstract

V originále

Background: Local treatment improves the outcomes for oligometastatic disease (OMD, i.e. an intermediate state between locoregional and widespread disseminated disease). However, consensus about the definition, diagnosis and treatment of oligometastatic oesopha-gogastric cancer is lacking. The aim of this study was to develop a multidisciplinary European consensus statement on the definition, diagnosis and treatment of oligometastatic oesophago-gastric cancer. Methods: In total, 65 specialists in the multidisciplinary treatment for oesophagogastric cancer from 49 expert centres across 16 European countries were requested to participate in this Del-phi study. The consensus finding process consisted of a starting meeting, 2 online Delphi ques-tionnaire rounds and an online consensus meeting. Input for Delphi questionnaires consisted of (1) a systematic review on definitions of oligometastatic oesophagogastric cancer and (2) a discussion of real-life clinical cases by multidisciplinary teams. Experts were asked to score each statement on a 5-point Likert scale. The agreement was scored to be either absent/poor (<50%), fair (50%-75%) or consensus (>75%). Results: A total of 48 experts participated in the starting meeting, both Delphi rounds, and the consensus meeting (overall response rate: 71%). OMD was considered in patients with meta-static oesophagogastric cancer limited to 1 organ with <3 metastases or 1 extra-regional lymph node station (consensus). In addition, OMD was considered in patients without pro-gression at restaging after systemic therapy (consensus). For patients with synchronous or me-tachronous OMD with a disease-free interval <2 years, systemic therapy followed by restaging to consider local treatment was considered as treatment (consensus). For metachronous OMD with a disease-free interval >2 years, either upfront local treatment or systemic treatment fol-lowed by restaging was considered as treatment (fair agreement). Conclusion: The OMEC project has resulted in a multidisciplinary European consensus state -ment for the definition, diagnosis and treatment of oligometastatic oesophagogastric adeno-carcinoma and squamous cell cancer. This can be used to standardise inclusion criteria for future clinical trials. 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Citovat

KROESE, Tiuri E, Hanneke W M VAN LAARHOVEN, Sebastian F SCHOPPMAN, Pieter R A J DESEYNE, Eric VAN CUTSEM, Karin HAUSTERMANS, Philippe NAFTEUX, Melissa THOMAS, Radka OBERMANNOVÁ, Hanna R MORTENSEN, Marianne NORDSMARK, Per PFEIFFER, Anneli ELME, Antoine ADENIS, Guillaume PIESSEN, Christiane J BRUNS, Florian LORDICK, Ines GOCKEL, Markus MOEHLER, Cihan GANI, Theodore LIAKAKOS, John REYNOLDS, Alessio G MORGANTI, Riccardo ROSATI, Carlo CASTORO, Francesco CELLINI, Domenico UGO, Franco ROVIELLO, Maria BENCIVENGA, Giovanni DE MANZONI, Mark I van Berge HENEGOUWEN, Maarten C C M HULSHOF, van Dieren JOLANDA, Marieke VOLLEBERGH, Johanna W VAN SANDICK, Paul JEENE, Christel T MUIJS, Marije SLINGERLAND, Francine E M VONCKEN, Henk HARTGRINK, Geert-Jan CREEMERS, Maurice J C VAN DER SANGEN, Grard NIEUWENHUIJZEN, Maaike BERBEE, Marcel VERHEIJ, Bas WIJNHOVEN, V Beerepoot LAURENS, Nadia H MOHAMMAD, Stella MOOK, Jelle P RUURDA, Piotr KOLODZIEJCZYK, Wojciech P POLKOWSKI, Lucjan WYRWICZ, Maria ALSINA, Manuel PERA, Tania F KANONNIKOFF, Andres CERVANTES, Magnus NILSSON, Stefan MONIG, Anna D WAGNER, Matthias GUCKENBERGER, Ewen A GRIFFITHS, Elizabeth SMYTH, George B HANNA, Sheraz MARKAR, M Asif CHAUDRY, Maria A HAWKINS, Edward CHEONG, Richard VAN HILLEGERSBERG and Peter S N VAN ROSSUM. Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe. European Journal of Cancer. Oxford: Elsevier Science Inc., 2023, vol. 185, No 12, p. 28-39. ISSN 0959-8049. Available from: https://dx.doi.org/10.1016/j.ejca.2023.02.015.

@article{2292983,
   author = {Kroese, Tiuri E and van Laarhoven, Hanneke W M and Schoppman, Sebastian F and Deseyne, Pieter R A J and van Cutsem, Eric and Haustermans, Karin and Nafteux, Philippe and Thomas, Melissa and Obermannová, Radka and Mortensen, Hanna R and Nordsmark, Marianne and Pfeiffer, Per and Elme, Anneli and Adenis, Antoine and Piessen, Guillaume and Bruns, Christiane J and Lordick, Florian and Gockel, Ines and Moehler, Markus and Gani, Cihan and Liakakos, Theodore and Reynolds, John and Morganti, Alessio G and Rosati, Riccardo and Castoro, Carlo and Cellini, Francesco and Ugo, Domenico and Roviello, Franco and Bencivenga, Maria and de Manzoni, Giovanni and Henegouwen, Mark I van Berge and Hulshof, Maarten C C M and Jolanda, van Dieren and Vollebergh, Marieke and van Sandick, Johanna W and Jeene, Paul and Muijs, Christel T and Slingerland, Marije and Voncken, Francine E M and Hartgrink, Henk and Creemers, GeertandJan and van der Sangen, Maurice J C and Nieuwenhuijzen, Grard and Berbee, Maaike and Verheij, Marcel and Wijnhoven, Bas and Laurens, V Beerepoot and Mohammad, Nadia H and Mook, Stella and Ruurda, Jelle P and Kolodziejczyk, Piotr and Polkowski, Wojciech P and Wyrwicz, Lucjan and Alsina, Maria and Pera, Manuel and Kanonnikoff, Tania F and Cervantes, Andres and Nilsson, Magnus and Monig, Stefan and Wagner, Anna D and Guckenberger, Matthias and Griffiths, Ewen A and Smyth, Elizabeth and Hanna, George B and Markar, Sheraz and Chaudry, M Asif and Hawkins, Maria A and Cheong, Edward and van Hillegersberg, Richard and van Rossum, Peter S N},
   article_location = {Oxford},
   article_number = {12},
   doi = {http://dx.doi.org/10.1016/j.ejca.2023.02.015},
   keywords = {Oesophageal cancer; Gastric cancer; Metastasis; Metastasectomy; Stereotactic body radiotherapy; Oligometastasis},
   language = {eng},
   issn = {0959-8049},
   journal = {European Journal of Cancer},
   title = {Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe},
   url = {https://www.sciencedirect.com/science/article/pii/S095980492300103X?via%3Dihub},
   volume = {185},
   year = {2023}
}

TY  - JOUR
ID  - 2292983
AU  - Kroese, Tiuri E - van Laarhoven, Hanneke W M - Schoppman, Sebastian F - Deseyne, Pieter R A J - van Cutsem, Eric - Haustermans, Karin - Nafteux, Philippe - Thomas, Melissa - Obermannová, Radka - Mortensen, Hanna R - Nordsmark, Marianne - Pfeiffer, Per - Elme, Anneli - Adenis, Antoine - Piessen, Guillaume - Bruns, Christiane J - Lordick, Florian - Gockel, Ines - Moehler, Markus - Gani, Cihan - Liakakos, Theodore - Reynolds, John - Morganti, Alessio G - Rosati, Riccardo - Castoro, Carlo - Cellini, Francesco - Ugo, Domenico - Roviello, Franco - Bencivenga, Maria - de Manzoni, Giovanni - Henegouwen, Mark I van Berge - Hulshof, Maarten C C M - Jolanda, van Dieren - Vollebergh, Marieke - van Sandick, Johanna W - Jeene, Paul - Muijs, Christel T - Slingerland, Marije - Voncken, Francine E M - Hartgrink, Henk - Creemers, Geert-Jan - van der Sangen, Maurice J C - Nieuwenhuijzen, Grard - Berbee, Maaike - Verheij, Marcel - Wijnhoven, Bas - Laurens, V Beerepoot - Mohammad, Nadia H - Mook, Stella - Ruurda, Jelle P - Kolodziejczyk, Piotr - Polkowski, Wojciech P - Wyrwicz, Lucjan - Alsina, Maria - Pera, Manuel - Kanonnikoff, Tania F - Cervantes, Andres - Nilsson, Magnus - Monig, Stefan - Wagner, Anna D - Guckenberger, Matthias - Griffiths, Ewen A - Smyth, Elizabeth - Hanna, George B - Markar, Sheraz - Chaudry, M Asif - Hawkins, Maria A - Cheong, Edward - van Hillegersberg, Richard - van Rossum, Peter S N
PY  - 2023
TI  - Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe
JF  - European Journal of Cancer
VL  - 185
IS  - 12
SP  - 28-39
EP  - 28-39
PB  - Elsevier Science Inc.
SN  - 09598049
KW  - Oesophageal cancer
KW  - Gastric cancer
KW  - Metastasis
KW  - Metastasectomy
KW  - Stereotactic body radiotherapy
KW  - Oligometastasis
UR  - https://www.sciencedirect.com/science/article/pii/S095980492300103X?via%3Dihub
N2  - Background: Local treatment improves the outcomes for oligometastatic disease (OMD, i.e. an intermediate state between locoregional and widespread disseminated disease). However, consensus about the definition, diagnosis and treatment of oligometastatic oesopha-gogastric cancer is lacking. The aim of this study was to develop a multidisciplinary European consensus statement on the definition, diagnosis and treatment of oligometastatic oesophago-gastric cancer. Methods: In total, 65 specialists in the multidisciplinary treatment for oesophagogastric cancer from 49 expert centres across 16 European countries were requested to participate in this Del-phi study. The consensus finding process consisted of a starting meeting, 2 online Delphi ques-tionnaire rounds and an online consensus meeting. Input for Delphi questionnaires consisted of (1) a systematic review on definitions of oligometastatic oesophagogastric cancer and (2) a discussion of real-life clinical cases by multidisciplinary teams. Experts were asked to score each statement on a 5-point Likert scale. The agreement was scored to be either absent/poor (<50%), fair (50%-75%) or consensus (>75%). Results: A total of 48 experts participated in the starting meeting, both Delphi rounds, and the consensus meeting (overall response rate: 71%). OMD was considered in patients with meta-static oesophagogastric cancer limited to 1 organ with <3 metastases or 1 extra-regional lymph node station (consensus). In addition, OMD was considered in patients without pro-gression at restaging after systemic therapy (consensus). For patients with synchronous or me-tachronous OMD with a disease-free interval <2 years, systemic therapy followed by restaging to consider local treatment was considered as treatment (consensus). For metachronous OMD with a disease-free interval >2 years, either upfront local treatment or systemic treatment fol-lowed by restaging was considered as treatment (fair agreement). Conclusion: The OMEC project has resulted in a multidisciplinary European consensus state -ment for the definition, diagnosis and treatment of oligometastatic oesophagogastric adeno-carcinoma and squamous cell cancer. This can be used to standardise inclusion criteria for future clinical trials. 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
ER  -

KROESE, Tiuri E, Hanneke W M VAN LAARHOVEN, Sebastian F SCHOPPMAN, Pieter R A J DESEYNE, Eric VAN CUTSEM, Karin HAUSTERMANS, Philippe NAFTEUX, Melissa THOMAS, Radka OBERMANNOVÁ, Hanna R MORTENSEN, Marianne NORDSMARK, Per PFEIFFER, Anneli ELME, Antoine ADENIS, Guillaume PIESSEN, Christiane J BRUNS, Florian LORDICK, Ines GOCKEL, Markus MOEHLER, Cihan GANI, Theodore LIAKAKOS, John REYNOLDS, Alessio G MORGANTI, Riccardo ROSATI, Carlo CASTORO, Francesco CELLINI, Domenico UGO, Franco ROVIELLO, Maria BENCIVENGA, Giovanni DE MANZONI, Mark I van Berge HENEGOUWEN, Maarten C C M HULSHOF, van Dieren JOLANDA, Marieke VOLLEBERGH, Johanna W VAN SANDICK, Paul JEENE, Christel T MUIJS, Marije SLINGERLAND, Francine E M VONCKEN, Henk HARTGRINK, Geert-Jan CREEMERS, Maurice J C VAN DER SANGEN, Grard NIEUWENHUIJZEN, Maaike BERBEE, Marcel VERHEIJ, Bas WIJNHOVEN, V Beerepoot LAURENS, Nadia H MOHAMMAD, Stella MOOK, Jelle P RUURDA, Piotr KOLODZIEJCZYK, Wojciech P POLKOWSKI, Lucjan WYRWICZ, Maria ALSINA, Manuel PERA, Tania F KANONNIKOFF, Andres CERVANTES, Magnus NILSSON, Stefan MONIG, Anna D WAGNER, Matthias GUCKENBERGER, Ewen A GRIFFITHS, Elizabeth SMYTH, George B HANNA, Sheraz MARKAR, M Asif CHAUDRY, Maria A HAWKINS, Edward CHEONG, Richard VAN HILLEGERSBERG and Peter S N VAN ROSSUM. Definition, diagnosis and treatment of oligometastatic oesophagogastric cancer: A Delphi consensus study in Europe. \textit{European Journal of Cancer}. Oxford: Elsevier Science Inc., 2023, vol.~185, No~12, p.~28-39. ISSN~0959-8049. Available from: https://dx.doi.org/10.1016/j.ejca.2023.02.015.

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