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@article{2293083,
author = {Musilová, Tereza and Jonas, Jakub and Gombala, Tomas and David, Jan and Fencl, Filip and Klabusayová, Eva and Klučka, Jozef and Kratochvíl, Milan and Havránková, Pavla and Vrtkova, Adela and Slabá, Kateřina and Tučková, Jana and Homola, Lukáš and Štourač, Petr and Vymazal, Tomáš},
article_location = {BASEL},
article_number = {2},
doi = {http://dx.doi.org/10.3390/children10020348},
keywords = {PIMS-TS; COVID-19; SARS-CoV-2; paediatric patient; post-COVID syndrome},
language = {eng},
issn = {2227-9067},
journal = {Children},
title = {COVID-19-Associated Paediatric Inflammatory Multisystem Syndrome (PIMS-TS) in Intensive Care: A Retrospective Cohort Trial (PIMS-TS INT)},
url = {https://www.mdpi.com/2227-9067/10/2/348},
volume = {10},
year = {2023}
}
TY - JOUR
ID - 2293083
AU - Musilová, Tereza - Jonas, Jakub - Gombala, Tomas - David, Jan - Fencl, Filip - Klabusayová, Eva - Klučka, Jozef - Kratochvíl, Milan - Havránková, Pavla - Vrtkova, Adela - Slabá, Kateřina - Tučková, Jana - Homola, Lukáš - Štourač, Petr - Vymazal, Tomáš
PY - 2023
TI - COVID-19-Associated Paediatric Inflammatory Multisystem Syndrome (PIMS-TS) in Intensive Care: A Retrospective Cohort Trial (PIMS-TS INT)
JF - Children
VL - 10
IS - 2
SP - 1-15
EP - 1-15
PB - MDPI
SN - 22279067
KW - PIMS-TS
KW - COVID-19
KW - SARS-CoV-2
KW - paediatric patient
KW - post-COVID syndrome
UR - https://www.mdpi.com/2227-9067/10/2/348
N2 - Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) is a new disease in children and adolescents that occurs after often asymptomatic or mild COVID-19. It can be manifested by different clinical symptomatology and varying severity of disease based on multisystemic inflammation. The aim of this retrospective cohort trial was to describe the initial clinical presentation, diagnostics, therapy and clinical outcome of paediatric patients with a diagnosis of PIMS-TS admitted to one of the 3 PICUs. All paediatric patients who were admitted to the hospital with a diagnosis of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) during the study period were enrolled in the study. A total of 180 patients were analysed. The most common symptoms upon admission were fever (81.6%, n = 147), rash (70.6%, n = 127), conjunctivitis (68.9%, n = 124) and abdominal pain (51.1%, n = 92). Acute respiratory failure occurred in 21.1% of patients (n = 38). Vasopressor support was used in 20.6% (n = 37) of cases. Overall, 96.7% of patients (n = 174) initially tested positive for SARS-CoV-2 IgG antibodies. Almost all patients received antibiotics during in-hospital stays. No patient died during the hospital stay or after 28 days of follow-up. Initial clinical presentation and organ system involvement of PIMS-TS including laboratory manifestations and treatment were identified in this trial. Early identification of PIMS-TS manifestation is essential for early treatment and proper management of patients.
ER -
MUSILOVÁ, Tereza, Jakub JONAS, Tomas GOMBALA, Jan DAVID, Filip FENCL, Eva KLABUSAYOVÁ, Jozef KLUČKA, Milan KRATOCHVÍL, Pavla HAVRÁNKOVÁ, Adela VRTKOVA, Kateřina SLABÁ, Jana TUČKOVÁ, Lukáš HOMOLA, Petr ŠTOURAČ and Tomáš VYMAZAL. COVID-19-Associated Paediatric Inflammatory Multisystem Syndrome (PIMS-TS) in Intensive Care: A Retrospective Cohort Trial (PIMS-TS INT). \textit{Children}. BASEL: MDPI, 2023, vol.~10, No~2, p.~1-15. ISSN~2227-9067. Available from: https://dx.doi.org/10.3390/children10020348.
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