ŠKOVRANOVÁ, Gabriela, Lenka MOLČANOVÁ, Anja KLANČNIK, Blaž JUG, Sonja SMOLE-MOŽINA and Alice SYCHROVÁ. Paulownia tomentosa extracts fighting against staphylococcal biofilm formation. In 18th Warsaw International Medical Congress, 21st - 23rd April 2023. 2023.
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Basic information
Original name Paulownia tomentosa extracts fighting against staphylococcal biofilm formation
Authors ŠKOVRANOVÁ, Gabriela (703 Slovakia, guarantor, belonging to the institution), Lenka MOLČANOVÁ (703 Slovakia, belonging to the institution), Anja KLANČNIK (705 Slovenia), Blaž JUG (705 Slovenia), Sonja SMOLE-MOŽINA (705 Slovenia) and Alice SYCHROVÁ (203 Czech Republic, belonging to the institution).
Edition 18th Warsaw International Medical Congress, 21st - 23rd April 2023, 2023.
Other information
Original language English
Type of outcome Presentations at conferences
Field of Study 30104 Pharmacology and pharmacy
Confidentiality degree is not subject to a state or trade secret
WWW Abstracts Book
RIV identification code RIV/00216224:14160/23:00131050
Organization unit Faculty of Pharmacy
Keywords (in Czech) antimikrobiální aktivity; eradikace; Paulownia tomentosa; quorum-sensing; Staphylococcus aureus,
Keywords in English antimicrobial activity; eradication; Paulownia tomentosa; quorum-sensing; Staphylococcus aureus
Tags rivok, ÚMF, ÚPL
Changed by Changed by: PharmDr. Gabriela Škovranová, Ph.D., učo 507356. Changed: 22/6/2023 11:19.
Abstract
Staphylococcus aureus is challenging to treat especially if biofilm occurs. Prenylated phenolics provide a significant source of potent antimicrobial agents. Ethanolic extract of Paulownia tomentosa was rich in active compounds, but prenylated flavonoids were dominant in the chloroform fraction. MIC of ethanolic extract, chloroform fraction, and three flavonoids showed significant antimicrobial activity, while lower concentrations prolonged the lag phase. Selected compounds reduced the adhesion of bacteria to the abiotic surface, and also the measurement of bioluminescence showed inhibition of intercellular signaling in bacterial suspension treated with plant formulations.
Links
MUNI/A/1212/2022, interní kód MUName: Synergizmus prenylovaných flavonoidov s topickými antibiotikami v boji proti stafylokokovým infekciám rán
Investor: Masaryk University, Synergism of prenylated flavonoids with topical antibiotics combating staphylococcal infections in wounds
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