Detailed Information on Publication Record
2023
Paulownia tomentosa extracts fighting against staphylococcal biofilm formation
ŠKOVRANOVÁ, Gabriela, Lenka MOLČANOVÁ, Anja KLANČNIK, Blaž JUG, Sonja SMOLE-MOŽINA et. al.Basic information
Original name
Paulownia tomentosa extracts fighting against staphylococcal biofilm formation
Authors
ŠKOVRANOVÁ, Gabriela (703 Slovakia, guarantor, belonging to the institution), Lenka MOLČANOVÁ (703 Slovakia, belonging to the institution), Anja KLANČNIK (705 Slovenia), Blaž JUG (705 Slovenia), Sonja SMOLE-MOŽINA (705 Slovenia) and Alice SYCHROVÁ (203 Czech Republic, belonging to the institution)
Edition
18th Warsaw International Medical Congress, 21st - 23rd April 2023, 2023
Other information
Language
English
Type of outcome
Prezentace na konferencích
Field of Study
30104 Pharmacology and pharmacy
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14160/23:00131050
Organization unit
Faculty of Pharmacy
Keywords (in Czech)
antimikrobiální aktivity; eradikace; Paulownia tomentosa; quorum-sensing; Staphylococcus aureus,
Keywords in English
antimicrobial activity; eradication; Paulownia tomentosa; quorum-sensing; Staphylococcus aureus
Změněno: 22/6/2023 11:19, PharmDr. Gabriela Škovranová, Ph.D.
Abstract
V originále
Staphylococcus aureus is challenging to treat especially if biofilm occurs. Prenylated phenolics provide a significant source of potent antimicrobial agents. Ethanolic extract of Paulownia tomentosa was rich in active compounds, but prenylated flavonoids were dominant in the chloroform fraction. MIC of ethanolic extract, chloroform fraction, and three flavonoids showed significant antimicrobial activity, while lower concentrations prolonged the lag phase. Selected compounds reduced the adhesion of bacteria to the abiotic surface, and also the measurement of bioluminescence showed inhibition of intercellular signaling in bacterial suspension treated with plant formulations.
Links
| MUNI/A/1212/2022, interní kód MU |
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