Features of Mpox infection: The analysis of the data submitted
to the ID-IRI network

J 2023

Features of Mpox infection: The analysis of the data submitted to the ID-IRI network

RODRIGUEZ-MORALES, Alfonso J., Antonio CASCIO, Hakan Rana ERDEM, Massimiliano LANZAFAME, Antonella TAMMARO et. al.

Basic information

Original name

Features of Mpox infection: The analysis of the data submitted to the ID-IRI network

Authors

RODRIGUEZ-MORALES, Alfonso J. (170 Colombia), Antonio CASCIO (380 Italy), Hakan Rana ERDEM (792 Turkey), Massimiliano LANZAFAME (380 Italy), Antonella TAMMARO (380 Italy), Iva S. CHRISTOVA (100 Bulgaria), Amani Aly EL KHOLY (818 Egypt), Y. CAG (792 Turkey), Botond LAKATOS (348 Hungary), Corneliu Petru POPESCU (642 Romania), A. N. BARBOSA (76 Brazil), Juan Pablo ESCALERA-ANTEZANA (68 Plurinational State of Bolivia), José Arturo MARTÍNEZ-OROZCO (484 Mexico), Enrique CHACÓN-CRUZ (840 United States of America), Hülya ÇAŞKURLU (792 Turkey), Ricardo Coll FERNÁNDEZ (630 Puerto Rico), Gülden ESER-KARLIDAĞ (792 Turkey), Tarsila VIECELI (76 Brazil), Stefka T. KRUMOVA (100 Bulgaria), Roman STEBEL (203 Czech Republic, guarantor, belonging to the institution), Olumuyiwa Elijah ARIYO (566 Nigeria), Rusmir BALJIĆ (70 Bosnia and Herzegovina), Mireia Cairó LLOBELL (724 Spain), Éva Livia NAGY (348 Hungary), Raúl Adrián CRUZ-FLORES (484 Mexico), Umran S. ELBAHR (48 Bahrain), Osasona Oluwadamilola GIDEON (566 Nigeria), Marcelo Felipe BATALLANOS-HUARACHI (68 Plurinational State of Bolivia), Philippe BOSSI (250 France), Andrea CALDERON-SUAREZ (170 Colombia), Ruben CASTILLO-QUINO (68 Plurinational State of Bolivia), Christian GOMEZ-DAVILA (68 Plurinational State of Bolivia), Mario GOMEZ-ZEPEDA (484 Mexico), Greisha M. GONZALES (840 United States of America), Carlos Eduardo GONZALES-FLORES (68 Plurinational State of Bolivia), Andrea GONZALEZ-RODRIGUEZ (840 United States of America), Humberto GUDINO-SOLORIO (32 Argentina), Daniela MARTINEZ-NIEVES (724 Spain), Miriam MOREIRA-FLORES (68 Plurinational State of Bolivia), Augustus OSBORNE (694 Sierra Leone), Pedro PALMA (620 Portugal) and Buse TUNCER (792 Turkey)

Edition

New Microbes and New Infections, Oxford, Elsevier Ltd. 2023, 2052-2975

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30303 Infectious Diseases

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

text publikace

Impact factor

Impact factor: 4.000 in 2022

RIV identification code

RIV/00216224:14110/23:00131056

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.nmni.2023.101154

UT WoS

001044811300001

Keywords (in Czech)

mpox; ohnisko; vakcína proti planým neštovicím; mpox u HIV infikovaných

Keywords in English

mpox; outbreak; smallpox vaccine; HIV-Infected mpox

Abstract

V originále

Background Mpox is a rare zoonotic disease caused by the Mpox virus. On May 21, 2022, WHO announced the emergence of confirmed Mpox cases in countries outside the endemic areas in Central and West Africa. Methods This multicentre study was performed through the Infectious Diseases International Research Initiative network. Nineteen collaborating centres in 16 countries participated in the study. Consecutive cases with positive Mpoxv-DNA results by the polymerase chain reaction test were included in the study. Results The mean age of 647 patients included in the study was 34.5.98.6% of cases were males, 95.3% were homosexual-bisexual, and 92.2% had a history of sexual contact. History of smallpox vaccination was present in 3.4% of cases. The median incubation period was 7.0 days. The most common symptoms and signs were rashes in 99.5%, lymphadenopathy in 65.1%, and fever in 54.9%. HIV infection was present in 93.8% of cases, and 17.8% were followed up in the hospital for further treatment. In the two weeks before the rash, prodromal symptoms occurred in 52.8% of cases. The incubation period was 3.5 days shorter in HIV-infected Mpox cases with CD4 count <200/μL, we disclosed the presence of lymphadenopathy, a characteristic finding for Mpox, accompanied the disease to a lesser extent in cases with smallpox vaccination. Conclusions Mpox disseminates globally, not just in the endemic areas. Knowledge of clinical features, disease transmission kinetics, and rapid and effective implementation of public health measures are paramount, as reflected by our findings in this study.

Citovat

RODRIGUEZ-MORALES, Alfonso J., Antonio CASCIO, Hakan Rana ERDEM, Massimiliano LANZAFAME, Antonella TAMMARO, Iva S. CHRISTOVA, Amani Aly EL KHOLY, Y. CAG, Botond LAKATOS, Corneliu Petru POPESCU, A. N. BARBOSA, Juan Pablo ESCALERA-ANTEZANA, José Arturo MARTÍNEZ-OROZCO, Enrique CHACÓN-CRUZ, Hülya ÇAŞKURLU, Ricardo Coll FERNÁNDEZ, Gülden ESER-KARLIDAĞ, Tarsila VIECELI, Stefka T. KRUMOVA, Roman STEBEL, Olumuyiwa Elijah ARIYO, Rusmir BALJIĆ, Mireia Cairó LLOBELL, Éva Livia NAGY, Raúl Adrián CRUZ-FLORES, Umran S. ELBAHR, Osasona Oluwadamilola GIDEON, Marcelo Felipe BATALLANOS-HUARACHI, Philippe BOSSI, Andrea CALDERON-SUAREZ, Ruben CASTILLO-QUINO, Christian GOMEZ-DAVILA, Mario GOMEZ-ZEPEDA, Greisha M. GONZALES, Carlos Eduardo GONZALES-FLORES, Andrea GONZALEZ-RODRIGUEZ, Humberto GUDINO-SOLORIO, Daniela MARTINEZ-NIEVES, Miriam MOREIRA-FLORES, Augustus OSBORNE, Pedro PALMA and Buse TUNCER. Features of Mpox infection: The analysis of the data submitted to the ID-IRI network. New Microbes and New Infections. Oxford: Elsevier Ltd., 2023, vol. 53, June, p. 101154-101159. ISSN 2052-2975. Available from: https://dx.doi.org/10.1016/j.nmni.2023.101154.

@article{2293239,
   author = {RodriguezandMorales, Alfonso J. and Cascio, Antonio and Erdem, Hakan Rana and Lanzafame, Massimiliano and Tammaro, Antonella and Christova, Iva S. and El Kholy, Amani Aly and Cag, Y. and Lakatos, Botond and Popescu, Corneliu Petru and Barbosa, A. N. and EscaleraandAntezana, Juan Pablo and MartínezandOrozco, José Arturo and ChacónandCruz, Enrique and Çaşkurlu, Hülya and Fernández, Ricardo Coll and EserandKarlıdağ, Gülden and Vieceli, Tarsila and Krumova, Stefka T. and Stebel, Roman and Ariyo, Olumuyiwa Elijah and Baljić, Rusmir and Llobell, Mireia Cairó and Nagy, Éva Livia and CruzandFlores, Raúl Adrián and Elbahr, Umran S. and Gideon, Osasona Oluwadamilola and BatallanosandHuarachi, Marcelo Felipe and Bossi, Philippe and CalderonandSuarez, Andrea and CastilloandQuino, Ruben and GomezandDavila, Christian and GomezandZepeda, Mario and Gonzales, Greisha M. and GonzalesandFlores, Carlos Eduardo and GonzalezandRodriguez, Andrea and GudinoandSolorio, Humberto and MartinezandNieves, Daniela and MoreiraandFlores, Miriam and Osborne, Augustus and Palma, Pedro and Tuncer, Buse},
   article_location = {Oxford},
   article_number = {June},
   doi = {http://dx.doi.org/10.1016/j.nmni.2023.101154},
   keywords = {mpox; outbreak; smallpox vaccine; HIV-Infected mpox},
   language = {eng},
   issn = {2052-2975},
   journal = {New Microbes and New Infections},
   title = {Features of Mpox infection: The analysis of the data submitted to the ID-IRI network},
   url = {https://www.sciencedirect.com/science/article/pii/S2052297523000732?via%3Dihub},
   volume = {53},
   year = {2023}
}

TY  - JOUR
ID  - 2293239
AU  - Rodriguez-Morales, Alfonso J. - Cascio, Antonio - Erdem, Hakan Rana - Lanzafame, Massimiliano - Tammaro, Antonella - Christova, Iva S. - El Kholy, Amani Aly - Cag, Y. - Lakatos, Botond - Popescu, Corneliu Petru - Barbosa, A. N. - Escalera-Antezana, Juan Pablo - Martínez-Orozco, José Arturo - Chacón-Cruz, Enrique - Çaşkurlu, Hülya - Fernández, Ricardo Coll - Eser-Karlıdağ, Gülden - Vieceli, Tarsila - Krumova, Stefka T. - Stebel, Roman - Ariyo, Olumuyiwa Elijah - Baljić, Rusmir - Llobell, Mireia Cairó - Nagy, Éva Livia - Cruz-Flores, Raúl Adrián - Elbahr, Umran S. - Gideon, Osasona Oluwadamilola - Batallanos-Huarachi, Marcelo Felipe - Bossi, Philippe - Calderon-Suarez, Andrea - Castillo-Quino, Ruben - Gomez-Davila, Christian - Gomez-Zepeda, Mario - Gonzales, Greisha M. - Gonzales-Flores, Carlos Eduardo - Gonzalez-Rodriguez, Andrea - Gudino-Solorio, Humberto - Martinez-Nieves, Daniela - Moreira-Flores, Miriam - Osborne, Augustus - Palma, Pedro - Tuncer, Buse
PY  - 2023
TI  - Features of Mpox infection: The analysis of the data submitted to the ID-IRI network
JF  - New Microbes and New Infections
VL  - 53
IS  - June
SP  - 101154
EP  - 101154
PB  - Elsevier Ltd.
SN  - 20522975
KW  - mpox
KW  - outbreak
KW  - smallpox vaccine
KW  - HIV-Infected mpox
UR  - https://www.sciencedirect.com/science/article/pii/S2052297523000732?via%3Dihub
N2  - Background Mpox is a rare zoonotic disease caused by the Mpox virus. On May 21, 2022, WHO announced the emergence of confirmed Mpox cases in countries outside the endemic areas in Central and West Africa. Methods This multicentre study was performed through the Infectious Diseases International Research Initiative network. Nineteen collaborating centres in 16 countries participated in the study. Consecutive cases with positive Mpoxv-DNA results by the polymerase chain reaction test were included in the study. Results The mean age of 647 patients included in the study was 34.5.98.6% of cases were males, 95.3% were homosexual-bisexual, and 92.2% had a history of sexual contact. History of smallpox vaccination was present in 3.4% of cases. The median incubation period was 7.0 days. The most common symptoms and signs were rashes in 99.5%, lymphadenopathy in 65.1%, and fever in 54.9%. HIV infection was present in 93.8% of cases, and 17.8% were followed up in the hospital for further treatment. In the two weeks before the rash, prodromal symptoms occurred in 52.8% of cases. The incubation period was 3.5 days shorter in HIV-infected Mpox cases with CD4 count <200/μL, we disclosed the presence of lymphadenopathy, a characteristic finding for Mpox, accompanied the disease to a lesser extent in cases with smallpox vaccination. Conclusions Mpox disseminates globally, not just in the endemic areas. Knowledge of clinical features, disease transmission kinetics, and rapid and effective implementation of public health measures are paramount, as reflected by our findings in this study.
ER  -

RODRIGUEZ-MORALES, Alfonso J., Antonio CASCIO, Hakan Rana ERDEM, Massimiliano LANZAFAME, Antonella TAMMARO, Iva S. CHRISTOVA, Amani Aly EL KHOLY, Y. CAG, Botond LAKATOS, Corneliu Petru POPESCU, A. N. BARBOSA, Juan Pablo ESCALERA-ANTEZANA, José Arturo MARTÍNEZ-OROZCO, Enrique CHACÓN-CRUZ, Hülya $\backslash$C CA$\backslash$C SKURLU, Ricardo Coll FERNÁNDEZ, Gülden ESER-KARLIDAĞ, Tarsila VIECELI, Stefka T. KRUMOVA, Roman STEBEL, Olumuyiwa Elijah ARIYO, Rusmir BALJI$\backslash$'C, Mireia Cairó LLOBELL, Éva Livia NAGY, Raúl Adrián CRUZ-FLORES, Umran S. ELBAHR, Osasona Oluwadamilola GIDEON, Marcelo Felipe BATALLANOS-HUARACHI, Philippe BOSSI, Andrea CALDERON-SUAREZ, Ruben CASTILLO-QUINO, Christian GOMEZ-DAVILA, Mario GOMEZ-ZEPEDA, Greisha M. GONZALES, Carlos Eduardo GONZALES-FLORES, Andrea GONZALEZ-RODRIGUEZ, Humberto GUDINO-SOLORIO, Daniela MARTINEZ-NIEVES, Miriam MOREIRA-FLORES, Augustus OSBORNE, Pedro PALMA and Buse TUNCER. Features of Mpox infection: The analysis of the data submitted to the ID-IRI network. \textit{New Microbes and New Infections}. Oxford: Elsevier Ltd., 2023, vol.~53, June, p.~101154-101159. ISSN~2052-2975. Available from: https://dx.doi.org/10.1016/j.nmni.2023.101154.

Detailed Information on Publication Record