Plasticity of Dental Cell Types in Development, Regeneration,
and Evolution

J 2023

Plasticity of Dental Cell Types in Development, Regeneration, and Evolution

KŘIVÁNEK, Jan, Marcela BUCHTOVÁ, K. FRIED and I. ADAMEYKO

Basic information

Original name

Plasticity of Dental Cell Types in Development, Regeneration, and Evolution

Authors

KŘIVÁNEK, Jan (203 Czech Republic, belonging to the institution), Marcela BUCHTOVÁ (203 Czech Republic), K. FRIED and I. ADAMEYKO

Edition

Journal of Dental Research, THOUSAND OAKS, SAGE PUBLICATIONS INC, 2023, 0022-0345

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10605 Developmental biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 7.600 in 2022

RIV identification code

RIV/00216224:14110/23:00134154

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1177/00220345231154800

UT WoS

000949948000001

Keywords in English

tooth development; stem cell(s); developmental biology; dental informatics; bioinformatics; single-cell RNA-seq; cell differentiation

Abstract

V originále

Recent years have improved our understanding of the plasticity of cell types behind inducing, building, and maintaining different types of teeth. The latest efforts were aided by progress in single-cell transcriptomics, which helped to define not only cell states with mathematical precision but also transitions between them. This includes new aspects of dental epithelial and mesenchymal stem cell niches and beyond. These recent efforts revealed continuous and fluid trajectories connecting cell states during dental development and exposed the natural plasticity of tooth-building progenitors. Such "developmental" plasticity seems to be employed for organizing stem cell niches in adult continuously growing teeth. Furthermore, transitions between mature cell types elicited by trauma might represent a replay of embryonic continuous cell states. Alternatively, they could constitute transitions that evolved de novo, not known from the developmental paradigm. In this review, we discuss and exemplify how dental cell types exhibit plasticity during dynamic processes such as development, self-renewal, repair, and dental replacement. Hypothetically, minor plasticity of cell phenotypes and greater plasticity of transitions between cell subtypes might provide a better response to lifetime challenges, such as damage or dental loss. This plasticity might be additionally harnessed by the evolutionary process during the elaboration of dental cell subtypes in different animal lineages. In turn, the diversification of cell subtypes building teeth brings a diversity of their shape, structural properties, and functions.

Links

GA23-06160S, research and development project

Name: Fluktuace mikroprostředí kmenových buněk jako zdroj tkáňové adaptability ve zdraví a nemoci

Investor: Czech Science Foundation, Fluctuation of the stem cell niche as a source of tissue adaptability in health and disease

Citovat

KŘIVÁNEK, Jan, Marcela BUCHTOVÁ, K. FRIED and I. ADAMEYKO. Plasticity of Dental Cell Types in Development, Regeneration, and Evolution. Journal of Dental Research. THOUSAND OAKS: SAGE PUBLICATIONS INC, 2023, vol. 102, No 6, p. 589-598. ISSN 0022-0345. Available from: https://dx.doi.org/10.1177/00220345231154800.

@article{2294559,
   author = {Křivánek, Jan and Buchtová, Marcela and Fried, K. and Adameyko, I.},
   article_location = {THOUSAND OAKS},
   article_number = {6},
   doi = {http://dx.doi.org/10.1177/00220345231154800},
   keywords = {tooth development; stem cell(s); developmental biology; dental informatics; bioinformatics; single-cell RNA-seq; cell differentiation},
   language = {eng},
   issn = {0022-0345},
   journal = {Journal of Dental Research},
   title = {Plasticity of Dental Cell Types in Development, Regeneration, and Evolution},
   url = {https://journals.sagepub.com/doi/10.1177/00220345231154800},
   volume = {102},
   year = {2023}
}

TY  - JOUR
ID  - 2294559
AU  - Křivánek, Jan - Buchtová, Marcela - Fried, K. - Adameyko, I.
PY  - 2023
TI  - Plasticity of Dental Cell Types in Development, Regeneration, and Evolution
JF  - Journal of Dental Research
VL  - 102
IS  - 6
SP  - 589-598
EP  - 589-598
PB  - SAGE PUBLICATIONS INC
SN  - 00220345
KW  - tooth development
KW  - stem cell(s)
KW  - developmental biology
KW  - dental informatics
KW  - bioinformatics
KW  - single-cell RNA-seq
KW  - cell differentiation
UR  - https://journals.sagepub.com/doi/10.1177/00220345231154800
N2  - Recent years have improved our understanding of the plasticity of cell types behind inducing, building, and maintaining different types of teeth. The latest efforts were aided by progress in single-cell transcriptomics, which helped to define not only cell states with mathematical precision but also transitions between them. This includes new aspects of dental epithelial and mesenchymal stem cell niches and beyond. These recent efforts revealed continuous and fluid trajectories connecting cell states during dental development and exposed the natural plasticity of tooth-building progenitors. Such "developmental" plasticity seems to be employed for organizing stem cell niches in adult continuously growing teeth. Furthermore, transitions between mature cell types elicited by trauma might represent a replay of embryonic continuous cell states. Alternatively, they could constitute transitions that evolved de novo, not known from the developmental paradigm. In this review, we discuss and exemplify how dental cell types exhibit plasticity during dynamic processes such as development, self-renewal, repair, and dental replacement. Hypothetically, minor plasticity of cell phenotypes and greater plasticity of transitions between cell subtypes might provide a better response to lifetime challenges, such as damage or dental loss. This plasticity might be additionally harnessed by the evolutionary process during the elaboration of dental cell subtypes in different animal lineages. In turn, the diversification of cell subtypes building teeth brings a diversity of their shape, structural properties, and functions.
ER  -

KŘIVÁNEK, Jan, Marcela BUCHTOVÁ, K. FRIED and I. ADAMEYKO. Plasticity of Dental Cell Types in Development, Regeneration, and Evolution. \textit{Journal of Dental Research}. THOUSAND OAKS: SAGE PUBLICATIONS INC, 2023, vol.~102, No~6, p.~589-598. ISSN~0022-0345. Available from: https://dx.doi.org/10.1177/00220345231154800.

Detailed Information on Publication Record