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@article{2294958,
author = {Raudenská, Martina and Balvan, Jan and Hánělová, Klára and Bugajová, Mária and Masařík, Michal},
article_location = {AMSTERDAM},
article_number = {5},
doi = {http://dx.doi.org/10.1016/j.bbcan.2023.188940},
keywords = {Head and neck cancer; Cancer-associated fibroblasts; Cancer therapy; Tumor microenvironment; Resistance to therapy},
language = {eng},
issn = {0304-419X},
journal = {Biochimica et Biophysica Acta (BBA) - Reviews on Cancer},
title = {Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling},
url = {https://www.sciencedirect.com/science/article/pii/S0304419X23000896?via%3Dihub},
volume = {1878},
year = {2023}
}
TY - JOUR
ID - 2294958
AU - Raudenská, Martina - Balvan, Jan - Hánělová, Klára - Bugajová, Mária - Masařík, Michal
PY - 2023
TI - Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling
JF - Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
VL - 1878
IS - 5
SP - 1-12
EP - 1-12
PB - ELSEVIER
SN - 0304419X
KW - Head and neck cancer
KW - Cancer-associated fibroblasts
KW - Cancer therapy
KW - Tumor microenvironment
KW - Resistance to therapy
UR - https://www.sciencedirect.com/science/article/pii/S0304419X23000896?via%3Dihub
N2 - Cancer-associated fibroblasts (CAFs) are involved in critical aspects of head and neck squamous cell carcinoma (HNSCC) pathogenesis, such as the formation of a tumor-permissive extracellular matrix structure, angiogenesis, or immune and metabolic reprogramming of the tumor microenvironment (TME), with implications for metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effect of CAFs in TME is likely to reflect the heterogeneity and plasticity of their population, with context-dependent effects on carcinogenesis. The specific properties of CAFs provide many targetable molecules that could play an important role in the future therapy of HNSCC. In this review article, we will focus on the role of CAFs in the TME of HNSCC tumors. We will also discuss clinically relevant agents targeting CAFs, their signals, and signaling pathways, which are activated by CAFs in cancer cells, with the potential for repurposing for HNSCC therapy.
ER -
RAUDENSKÁ, Martina, Jan BALVAN, Klára HÁNĚLOVÁ, Mária BUGAJOVÁ and Michal MASAŘÍK. Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling. \textit{Biochimica et Biophysica Acta (BBA) - Reviews on Cancer}. AMSTERDAM: ELSEVIER, 2023, vol.~1878, No~5, p.~1-12. ISSN~0304-419X. Available from: https://dx.doi.org/10.1016/j.bbcan.2023.188940.
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