Cancer-associated fibroblasts: Mediators of head and neck tumor
microenvironment remodeling

J 2023

Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling

RAUDENSKÁ, Martina, Jan BALVAN, Klára HÁNĚLOVÁ, Mária BUGAJOVÁ, Michal MASAŘÍK et. al.

Basic information

Original name

Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling

Authors

RAUDENSKÁ, Martina (203 Czech Republic, belonging to the institution), Jan BALVAN (203 Czech Republic, belonging to the institution), Klára HÁNĚLOVÁ (203 Czech Republic, belonging to the institution), Mária BUGAJOVÁ (703 Slovakia, belonging to the institution) and Michal MASAŘÍK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, AMSTERDAM, ELSEVIER, 2023, 0304-419X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 11.200 in 2022

RIV identification code

RIV/00216224:14110/23:00131127

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.bbcan.2023.188940

UT WoS

001057815400001

Keywords in English

Head and neck cancer; Cancer-associated fibroblasts; Cancer therapy; Tumor microenvironment; Resistance to therapy

Abstract

V originále

Cancer-associated fibroblasts (CAFs) are involved in critical aspects of head and neck squamous cell carcinoma (HNSCC) pathogenesis, such as the formation of a tumor-permissive extracellular matrix structure, angiogenesis, or immune and metabolic reprogramming of the tumor microenvironment (TME), with implications for metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effect of CAFs in TME is likely to reflect the heterogeneity and plasticity of their population, with context-dependent effects on carcinogenesis. The specific properties of CAFs provide many targetable molecules that could play an important role in the future therapy of HNSCC. In this review article, we will focus on the role of CAFs in the TME of HNSCC tumors. We will also discuss clinically relevant agents targeting CAFs, their signals, and signaling pathways, which are activated by CAFs in cancer cells, with the potential for repurposing for HNSCC therapy.

Links

GA21-06873S, research and development project

Name: Metabolická symbióza mezi nádorovými buňkami a fibroblasty asociovaných s nádorem u nádorů v oblasti hlavy a krku

Investor: Czech Science Foundation

MUNI/A/1343/2022, interní kód MU

Name: Zátěže kardiovaskulárního systému od A po Z

Investor: Masaryk University, Loads on the cardiovascular system from A to Z

MUNI/A/1370/2022, interní kód MU

Name: Patofyziologie vybraných komplexních nemocí od molekulární do systémovou úroveň

Investor: Masaryk University, Pathophysiology of selected complex diseases from molecular to systemic level

NU22-03-00202, research and development project

Name: Proteom extracelulárních vezikul - neprozkoumaná oblast mezibuněčné komunikace v mikroprostředí nádorů hlavy a krku

Investor: Ministry of Health of the CR, Subprogram 1 - standard

Citovat

RAUDENSKÁ, Martina, Jan BALVAN, Klára HÁNĚLOVÁ, Mária BUGAJOVÁ and Michal MASAŘÍK. Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. AMSTERDAM: ELSEVIER, 2023, vol. 1878, No 5, p. 1-12. ISSN 0304-419X. Available from: https://dx.doi.org/10.1016/j.bbcan.2023.188940.

@article{2294958,
   author = {Raudenská, Martina and Balvan, Jan and Hánělová, Klára and Bugajová, Mária and Masařík, Michal},
   article_location = {AMSTERDAM},
   article_number = {5},
   doi = {http://dx.doi.org/10.1016/j.bbcan.2023.188940},
   keywords = {Head and neck cancer; Cancer-associated fibroblasts; Cancer therapy; Tumor microenvironment; Resistance to therapy},
   language = {eng},
   issn = {0304-419X},
   journal = {Biochimica et Biophysica Acta (BBA) - Reviews on Cancer},
   title = {Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling},
   url = {https://www.sciencedirect.com/science/article/pii/S0304419X23000896?via%3Dihub},
   volume = {1878},
   year = {2023}
}

TY  - JOUR
ID  - 2294958
AU  - Raudenská, Martina - Balvan, Jan - Hánělová, Klára - Bugajová, Mária - Masařík, Michal
PY  - 2023
TI  - Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling
JF  - Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
VL  - 1878
IS  - 5
SP  - 1-12
EP  - 1-12
PB  - ELSEVIER
SN  - 0304419X
KW  - Head and neck cancer
KW  - Cancer-associated fibroblasts
KW  - Cancer therapy
KW  - Tumor microenvironment
KW  - Resistance to therapy
UR  - https://www.sciencedirect.com/science/article/pii/S0304419X23000896?via%3Dihub
N2  - Cancer-associated fibroblasts (CAFs) are involved in critical aspects of head and neck squamous cell carcinoma (HNSCC) pathogenesis, such as the formation of a tumor-permissive extracellular matrix structure, angiogenesis, or immune and metabolic reprogramming of the tumor microenvironment (TME), with implications for metastasis and resistance to radiotherapy and chemotherapy. The pleiotropic effect of CAFs in TME is likely to reflect the heterogeneity and plasticity of their population, with context-dependent effects on carcinogenesis. The specific properties of CAFs provide many targetable molecules that could play an important role in the future therapy of HNSCC. In this review article, we will focus on the role of CAFs in the TME of HNSCC tumors. We will also discuss clinically relevant agents targeting CAFs, their signals, and signaling pathways, which are activated by CAFs in cancer cells, with the potential for repurposing for HNSCC therapy.
ER  -

RAUDENSKÁ, Martina, Jan BALVAN, Klára HÁNĚLOVÁ, Mária BUGAJOVÁ and Michal MASAŘÍK. Cancer-associated fibroblasts: Mediators of head and neck tumor microenvironment remodeling. \textit{Biochimica et Biophysica Acta (BBA) - Reviews on Cancer}. AMSTERDAM: ELSEVIER, 2023, vol.~1878, No~5, p.~1-12. ISSN~0304-419X. Available from: https://dx.doi.org/10.1016/j.bbcan.2023.188940.

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