| LABOHÁ, Petra, Eliška SYCHROVÁ, Ondřej BRÓZMAN, Iva SOVADINOVÁ, Lucie BLÁHOVÁ, Roman PROKEŠ, Jakub ONDRACEK and Pavel BABICA. Cyanobacteria, cyanotoxins and lipopolysaccharides in aerosols from inland freshwater bodies and their effects on human bronchial cells. Environmental Toxicology and Pharmacology. Amsterdam: Elsevier Science B.V., 2023, vol. 98, March 2023, p. 1-15. ISSN 1382-6689. Available from: https://dx.doi.org/10.1016/j.etap.2023.104073. |
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@article{2296306,
author = {Labohá, Petra and Sychrová, Eliška and Brózman, Ondřej and Sovadinová, Iva and Bláhová, Lucie and Prokeš, Roman and Ondracek, Jakub and Babica, Pavel},
article_location = {Amsterdam},
article_number = {March 2023},
doi = {http://dx.doi.org/10.1016/j.etap.2023.104073},
keywords = {Aerosol; Cyanobacteria; Cyanotoxins; Lipopolysaccharides; Inflammation; Inhalation toxicity},
language = {eng},
issn = {1382-6689},
journal = {Environmental Toxicology and Pharmacology},
title = {Cyanobacteria, cyanotoxins and lipopolysaccharides in aerosols from inland freshwater bodies and their effects on human bronchial cells},
url = {https://www.sciencedirect.com/science/article/pii/S1382668923000145?via%3Dihub},
volume = {98},
year = {2023}
}
TY - JOUR
ID - 2296306
AU - Labohá, Petra - Sychrová, Eliška - Brózman, Ondřej - Sovadinová, Iva - Bláhová, Lucie - Prokeš, Roman - Ondracek, Jakub - Babica, Pavel
PY - 2023
TI - Cyanobacteria, cyanotoxins and lipopolysaccharides in aerosols from inland freshwater bodies and their effects on human bronchial cells
JF - Environmental Toxicology and Pharmacology
VL - 98
IS - March 2023
SP - 1-15
EP - 1-15
PB - Elsevier Science B.V.
SN - 13826689
KW - Aerosol
KW - Cyanobacteria
KW - Cyanotoxins
KW - Lipopolysaccharides
KW - Inflammation
KW - Inhalation toxicity
UR - https://www.sciencedirect.com/science/article/pii/S1382668923000145?via%3Dihub
N2 - Components of cyanobacterial water blooms were quantified in aerosols above agitated water surfaces of five freshwater bodies. The thoracic and respirable aerosol fraction (0.1-10 mu m) was sampled using a high-volume sampler. Cyanotoxins microcystins were detected by LC-MS/MS at levels 0.3-13.5 ng/mL (water) and < 35-415 fg/m3 (aerosol). Lipopolysaccharides (endotoxins) were quantified by Pyrogene rFC assay at levels < 10-119 EU/mL (water) and 0.13-0.64 EU/m3 (aerosol). Cyanobacterial DNA was detected by qPCR at con-centrations corresponding to 104-105 cells eq./mL (water) and 101-103 cells eq./m3 (aerosol). Lipopolysac-charides isolated from bloom samples induced IL-6 and IL-8 cytokine release in human bronchial epithelial cells Beas-2B, while extracted cyanobacterial metabolites induced both pro-inflammatory and cytotoxic effects. Bloom components detected in aerosols and their bioactivities observed in upper respiratory airway epithelial cells together indicate that aerosols formed during cyanobacterial water blooms could induce respiratory irritation and inflammatory injuries, and thus present an inhalation health risk.
ER -
LABOHÁ, Petra, Eliška SYCHROVÁ, Ondřej BRÓZMAN, Iva SOVADINOVÁ, Lucie BLÁHOVÁ, Roman PROKEŠ, Jakub ONDRACEK and Pavel BABICA. Cyanobacteria, cyanotoxins and lipopolysaccharides in aerosols from inland freshwater bodies and their effects on human bronchial cells. \textit{Environmental Toxicology and Pharmacology}. Amsterdam: Elsevier Science B.V., 2023, vol.~98, March 2023, p.~1-15. ISSN~1382-6689. Available from: https://dx.doi.org/10.1016/j.etap.2023.104073.
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