a 2023

Microbiome and pharmacotherapy in patients with gastrointestinal disorders

MLČŮCHOVÁ, Natálie and Petra BOŘILOVÁ LINHARTOVÁ

Basic information

Original name

Microbiome and pharmacotherapy in patients with gastrointestinal disorders

Authors

MLČŮCHOVÁ, Natálie (203 Czech Republic, belonging to the institution) and Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, guarantor)

Edition

RECETOX PhD Conference 2023, 2023

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30101 Human genetics

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/23:00134642

Organization unit

Faculty of Science

Keywords in English

microbiome;pharmacotherapy;gastrointestinal disorders
Změněno: 7/7/2023 10:53, Mgr. Terezie Slámová

Abstract

V originále

Background: Etiopathogenesis of gastrointestinal disorders (GDs), such as gastroesophageal reflux disease (GERD) and its complications, pancreatic cancer (PANC), and colorectal adenocarcinoma (CRC) is multifactorial; risk factors for disease development and/or progression include external factors, dysbiosis of host microbiota, genetic predisposition, and responsiveness to therapy. Objectives: The main aim of the dissertation project is to identify potential markers at the level of the host microbiome. Methods: Human and microbial DNA will be isolated from blood and biopsies from the digestive tract. Microbial DNA will be analyzed by 16S rRNA amplicon sequencing and quantified by multiplex qPCR method. Outcomes: Paired comparison of bacteriomes between healthy and pathological parts of the digestive tract will be performed to identify potentially risky host bacteriome profiles.

Links

NU20-03-00126, research and development project
Name: Hostitelský mikrobiom ve vztahu k rozvoji Barrettova jícnu a adenokarcinomu jícnu
Investor: Ministry of Health of the CR, Host microbiome in relation to Barrett ́s esophagus and esophageal adenocarcinoma development, Subprogram 1 - standard