a 2023

The effect of intrapartum antibiotics prophylaxis on neonatal gut and oral bacteriome

PIVRNCOVÁ, Eliška, Iva KOTÁSKOVÁ, Lucie BUREŠOVÁ, Lenka ANDRÝSKOVÁ, Pavel PILER et. al.

Basic information

Original name

The effect of intrapartum antibiotics prophylaxis on neonatal gut and oral bacteriome

Authors

PIVRNCOVÁ, Eliška (203 Czech Republic, belonging to the institution), Iva KOTÁSKOVÁ (203 Czech Republic), Lucie BUREŠOVÁ (203 Czech Republic), Lenka ANDRÝSKOVÁ (203 Czech Republic), Pavel PILER (203 Czech Republic), Petr JANKŮ (203 Czech Republic), Ivo BOREK (203 Czech Republic), Jana KLÁNOVÁ (203 Czech Republic), Petra VÍDEŇSKÁ (203 Czech Republic), Eva BUDINSKÁ (703 Slovakia) and Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, guarantor)

Edition

RECETOX PhD Conference 2023, 2023

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/23:00131175

Organization unit

Faculty of Science

Keywords in English

antibiotics prophylaxis;neonatal gut;oral bacteriome
Změněno: 7/7/2023 11:13, Mgr. Terezie Slámová

Abstract

V originále

The administration of intrapartum antibiotics prophylaxis (IAP) is commonly used in cesarean section and for the prevention of early-onset Group-B-streptococci infection. Since IAP may influence the microbiome development in neonates, our pilot study aimed to characterize the gut and oral bacteriome changes between neonates grouped according to their exposure to antibiotics during the delivery and sampling time in the first week of their life. 16S rDNA sequencing revealed differences in bacterial abundance in transitional stool samples, but not in meconium samples. Moreover, IAP influenced the oral bacteriome of neonates within 48 hours after birth. However, the effect of IAP on oral bacteriome seems to be suppressed later in the first week of their life.

Links

EF17_043/0009632, research and development project
Name: CETOCOEN Excellence
LM2018132, research and development project
Name: Národní centrum lékařské genomiky (Acronym: NCLG)
Investor: Ministry of Education, Youth and Sports of the CR, National Center for Medical Genomics
LM2018140, research and development project
Name: e-Infrastruktura CZ (Acronym: e-INFRA CZ)
Investor: Ministry of Education, Youth and Sports of the CR
LM2023069, research and development project
Name: Výzkumná infrastruktura RECETOX
Investor: Ministry of Education, Youth and Sports of the CR, RECETOX research infrastructure