| MASURI, Sebastiano, Lukáš MORÁŇ, Tereza VESSELÁ, Enzo CADONI, Maria Grazia CABIDDU, Lukáš PEČINKA, Viktorie GABRIELOVÁ, Francesca MELONI, Josef HAVEL, Petr VAŇHARA and Tiziana PIVETTA. A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines. Journal of Inorganic Biochemistry. New York: Elsevier, 2023, vol. 246, September 2023, p. 1-14. ISSN 0162-0134. Available from: https://dx.doi.org/10.1016/j.jinorgbio.2023.112301. |
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@article{2296867,
author = {Masuri, Sebastiano and Moráň, Lukáš and Vesselá, Tereza and Cadoni, Enzo and Cabiddu, Maria Grazia and Pečinka, Lukáš and Gabrielová, Viktorie and Meloni, Francesca and Havel, Josef and Vaňhara, Petr and Pivetta, Tiziana},
article_location = {New York},
article_number = {September 2023},
doi = {http://dx.doi.org/10.1016/j.jinorgbio.2023.112301},
keywords = {Copper complex; Solution equilibria; Mass spectrometry; Lipoxygenase; Molecular docking; ER stress},
language = {eng},
issn = {0162-0134},
journal = {Journal of Inorganic Biochemistry},
title = {A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines},
url = {https://doi.org/10.1016/j.jinorgbio.2023.112301},
volume = {246},
year = {2023}
}
TY - JOUR
ID - 2296867
AU - Masuri, Sebastiano - Moráň, Lukáš - Vesselá, Tereza - Cadoni, Enzo - Cabiddu, Maria Grazia - Pečinka, Lukáš - Gabrielová, Viktorie - Meloni, Francesca - Havel, Josef - Vaňhara, Petr - Pivetta, Tiziana
PY - 2023
TI - A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines
JF - Journal of Inorganic Biochemistry
VL - 246
IS - September 2023
SP - 1-14
EP - 1-14
PB - Elsevier
SN - 01620134
KW - Copper complex
KW - Solution equilibria
KW - Mass spectrometry
KW - Lipoxygenase
KW - Molecular docking
KW - ER stress
UR - https://doi.org/10.1016/j.jinorgbio.2023.112301
N2 - A new heteroleptic copper(II) compound named C0-UDCA was prepared by reaction of [Cu(phen)2(OH2)](ClO4)2 (C0) with the bile ursodeoxycholic acid (UDCA). The resulting compound is able to inhibit the lipoxygenase enzyme showing more efficacy than the precursors C0 and UDCA. Molecular docking simulations clarified the interactions with the enzyme as due to allosteric modulation. The new complex shows antitumoral effect on ovarian (SKOV-3) and pancreatic (PANC-1) cancer cells at the Endoplasmic Reticulum (ER) level by activating the Unfolded Protein Response. In particular, the chaperone BiP, the pro-apoptotic protein CHOP and the transcription factor ATF6 are upregulated in the presence of C0-UDCA. The combination of Intact Cell MALDI-MS and statistical analysis have allowed us to discriminate between untreated and treated cells based on their mass spectrometry fingerprints.
ER -
MASURI, Sebastiano, Lukáš MORÁŇ, Tereza VESSELÁ, Enzo CADONI, Maria Grazia CABIDDU, Lukáš PEČINKA, Viktorie GABRIELOVÁ, Francesca MELONI, Josef HAVEL, Petr VAŇHARA and Tiziana PIVETTA. A novel heteroleptic Cu(II)-phenanthroline-UDCA complex as lipoxygenase inhibitor and ER-stress inducer in cancer cell lines. \textit{Journal of Inorganic Biochemistry}. New York: Elsevier, 2023, vol.~246, September 2023, p.~1-14. ISSN~0162-0134. Available from: https://dx.doi.org/10.1016/j.jinorgbio.2023.112301.
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