J 2023

Painless form of chronic pancreatitis-multicentre study

DITE, Petr, Marie PRECECHTELOVA, Martina BOJKOVA, Martin LOVECEK, Radek AMBROZ et. al.

Basic information

Original name

Painless form of chronic pancreatitis-multicentre study

Authors

DITE, Petr (203 Czech Republic, guarantor), Marie PRECECHTELOVA (203 Czech Republic), Martina BOJKOVA (203 Czech Republic), Martin LOVECEK (203 Czech Republic), Radek AMBROZ (203 Czech Republic), Arnost MARTINEK (203 Czech Republic) and Jiří DOLINA (203 Czech Republic, belonging to the institution)

Edition

Biomedical Papers, Olomouc: Palacky University, Olomouc, Palacky University, 2023, 1213-8118

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30219 Gastroenterology and hepatology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 0.900 in 2022

RIV identification code

RIV/00216224:14110/23:00131200

Organization unit

Faculty of Medicine

DOI

UT WoS

000996217700001

Keywords in English

pancreatic pain; painless form of pancreatitis; diabetes mellitus; pancreatic calcifications; exocrine insufficiency

Tags

Tags

International impact, Reviewed
Změněno: 11/7/2023 09:25, Mgr. Tereza Miškechová

Abstract

V originále

Background. The painless form of chronic pancreatitis is one of the rarer forms of the disease. While 80% to 90% of all chronic pancreatitis cases have abdominal pain as their clinical symptom, a smaller proportion of persons with chronic pancreatitis do not report typical pain. This form of the disease is often associated with exocrine and endocrine pancreatic insufficiency and weight loss, but the absence of pain symptoms may initially lead to misdiagnosis. Methods. In a cohort of 257 people with chronic pancreatitis, the painless form was diagnosed in 30 individuals (11.6%), with an average age of 56 years and a predominance of men (71.4%). Thirty-eight percent were non-smokers and 47.6% of patients smoked up to 10 cigarettes per day. Alcohol intake of less than 40 g per day was reported by 61.9% of subjects. A quarter were moderately overweight, with a mean BMI of 26.5. Newly diagnosed diabetes mellitus had 25.7% of the subjects.Results. A frequent finding was the demonstration of morphological changes, with calcifications found in 85,7% and dilatation of the pancreatic duct greater than 6.0 mm in 66%. A surprising finding was the presence of metabolic syndrome in 42.8% and the most frequent finding was the demonstration of decreased external pancreatic secretion (90%).Conclusion. Painless chronic pancreatitis is usually treated conservatively. We demonstrate a subset of 28 patients with painless chronic pancreatitis treated surgically. Most frequent indications were benign stenosis of the intrapancreatic bile duct and stenosis of the pancreatic duct. Although approximately 1 in 10 people with chronic pancreatitis present with a painless form of it, so that the form of the disease is described as rare, this does not change the fact that management of these people is still not optimal.