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@article{2297182,
author = {Rudzanová, Barbora and Vlaanderen, Jelle and Kalina, Jiří and Piler, Pavel and Zvonař, Martin and Klánová, Jana and Bláha, Luděk and Adamovský, Ondřej},
article_number = {July 2023},
doi = {http://dx.doi.org/10.1016/j.envres.2023.115969},
keywords = {Perfluoroalkyl substances; Immune system; Adult cohort; Allergy; Eczema; Bayesian kernel machine regression},
language = {eng},
issn = {0013-9351},
journal = {Environmental Research},
title = {Impact of PFAS exposure on prevalence of immune-mediated diseases in adults in the Czech Republic},
url = {https://www.sciencedirect.com/science/article/pii/S0013935123007612?via%3Dihub},
volume = {229},
year = {2023}
}
TY - JOUR
ID - 2297182
AU - Rudzanová, Barbora - Vlaanderen, Jelle - Kalina, Jiří - Piler, Pavel - Zvonař, Martin - Klánová, Jana - Bláha, Luděk - Adamovský, Ondřej
PY - 2023
TI - Impact of PFAS exposure on prevalence of immune-mediated diseases in adults in the Czech Republic
JF - Environmental Research
VL - 229
IS - July 2023
SP - 1-12
EP - 1-12
PB - Elsevier
SN - 00139351
KW - Perfluoroalkyl substances
KW - Immune system
KW - Adult cohort
KW - Allergy
KW - Eczema
KW - Bayesian kernel machine regression
UR - https://www.sciencedirect.com/science/article/pii/S0013935123007612?via%3Dihub
N2 - Background: Per-and polyfluoroalkyl substances (PFASs) are emerging environmental contaminants with mul-tiple hazardous properties including immunomodulation potency. Human exposure to PFASs has been associated with various immune-mediated diseases and outcomes. This study aimed to investigate the association between PFAS exposure and immune-mediated diseases such as allergies, eczemas, and autoimmune diseases in a pop-ulation of adults in the Czech Republic.Methods: This study included 309 adults from the Central European Longitudinal Study of Parents and Children: Young Adults (CELSPAC: YA). 12 PFASs were measured in participants' serum by HPLC-MS/MS, 3 PFASs were removed from the subsequent analyses due to low detection frequency. The associations of 9 PFASs with 9 immune-mediated diseases were assessed by logistic regression. Furthermore, Bayesian kernel machine regres-sion (BKMR) was used to estimate the effect of the PFAS mixture on immune-mediated diseases. All analyses were adjusted for sex, age, BMI, smoking, education, and family history of immune-mediated diseases. In cases of a statistically significant interaction of PFASs and sex, stratified analyses were performed for men and women.Results: Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) were negatively associated with both atopic eczema (OR per IQR increase 0.58 (95% CI 0.37-0.90) for PFOA and 0.56 (0.32-0.95) for PFOS) and contact dermatitis (0.37 (0.16-0.85) for PFOA and 0.33 (0.11-0.94) for PFOS). Perfluoroundecanoate (PFUnDA) was negatively associated with pollen, dust, and mite allergy (0.62 (0.43-0.89)). BKMR modelling showed a negative tendency in the overall effect of PFAS mixture on immune-health outcomes. Based on the stratified analysis, sex was suggested to be an effect modifier in the association of PFOS and atopic eczema.Conclusion: Our results contribute to the body of literature that observes the immunosuppressive effect of PFAS exposure during eczemas and allergies, both for PFASs individually and as a mixture.
ER -
RUDZANOVÁ, Barbora, Jelle VLAANDEREN, Jiří KALINA, Pavel PILER, Martin ZVONAŘ, Jana KLÁNOVÁ, Luděk BLÁHA and Ondřej ADAMOVSKÝ. Impact of PFAS exposure on prevalence of immune-mediated diseases in adults in the Czech Republic. \textit{Environmental Research}. Elsevier, 2023, vol.~229, July 2023, p.~1-12. ISSN~0013-9351. Available from: https://dx.doi.org/10.1016/j.envres.2023.115969.
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