Detailed Information on Publication Record
2023
Impact of PFAS exposure on prevalence of immune-mediated diseases in adults in the Czech Republic
RUDZANOVÁ, Barbora, Jelle VLAANDEREN, Jiří KALINA, Pavel PILER, Martin ZVONAŘ et. al.Basic information
Original name
Impact of PFAS exposure on prevalence of immune-mediated diseases in adults in the Czech Republic
Authors
RUDZANOVÁ, Barbora (203 Czech Republic, belonging to the institution), Jelle VLAANDEREN, Jiří KALINA (203 Czech Republic, belonging to the institution), Pavel PILER (203 Czech Republic, belonging to the institution), Martin ZVONAŘ (203 Czech Republic, belonging to the institution), Jana KLÁNOVÁ (203 Czech Republic, belonging to the institution), Luděk BLÁHA (203 Czech Republic, belonging to the institution) and Ondřej ADAMOVSKÝ (203 Czech Republic, guarantor, belonging to the institution)
Edition
Environmental Research, Elsevier, 2023, 0013-9351
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10511 Environmental sciences
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 8.300 in 2022
RIV identification code
RIV/00216224:14310/23:00131221
Organization unit
Faculty of Science
UT WoS
000992616900001
Keywords in English
Perfluoroalkyl substances; Immune system; Adult cohort; Allergy; Eczema; Bayesian kernel machine regression
Tags
Tags
International impact, Reviewed
Změněno: 8/3/2024 22:14, Mgr. Michaela Hylsová, Ph.D.
Abstract
V originále
Background: Per-and polyfluoroalkyl substances (PFASs) are emerging environmental contaminants with mul-tiple hazardous properties including immunomodulation potency. Human exposure to PFASs has been associated with various immune-mediated diseases and outcomes. This study aimed to investigate the association between PFAS exposure and immune-mediated diseases such as allergies, eczemas, and autoimmune diseases in a pop-ulation of adults in the Czech Republic.Methods: This study included 309 adults from the Central European Longitudinal Study of Parents and Children: Young Adults (CELSPAC: YA). 12 PFASs were measured in participants' serum by HPLC-MS/MS, 3 PFASs were removed from the subsequent analyses due to low detection frequency. The associations of 9 PFASs with 9 immune-mediated diseases were assessed by logistic regression. Furthermore, Bayesian kernel machine regres-sion (BKMR) was used to estimate the effect of the PFAS mixture on immune-mediated diseases. All analyses were adjusted for sex, age, BMI, smoking, education, and family history of immune-mediated diseases. In cases of a statistically significant interaction of PFASs and sex, stratified analyses were performed for men and women.Results: Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) were negatively associated with both atopic eczema (OR per IQR increase 0.58 (95% CI 0.37-0.90) for PFOA and 0.56 (0.32-0.95) for PFOS) and contact dermatitis (0.37 (0.16-0.85) for PFOA and 0.33 (0.11-0.94) for PFOS). Perfluoroundecanoate (PFUnDA) was negatively associated with pollen, dust, and mite allergy (0.62 (0.43-0.89)). BKMR modelling showed a negative tendency in the overall effect of PFAS mixture on immune-health outcomes. Based on the stratified analysis, sex was suggested to be an effect modifier in the association of PFOS and atopic eczema.Conclusion: Our results contribute to the body of literature that observes the immunosuppressive effect of PFAS exposure during eczemas and allergies, both for PFASs individually and as a mixture.
Links
| EF15_003/0000469, research and development project |
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| EF17_043/0009632, research and development project |
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| 857560, interní kód MU (CEP code: EF17_043/0009632) |
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| 90121, large research infrastructures |
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