Non-Invasive Diagnostics of Male Spermatogenesis from Seminal
Plasma: Seminal Proteins

J 2023

Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins

JEŠETA, Michal, Anna POSPÍŠILOVÁ, Lenka MEKIŇOVÁ, Kateřina FRANZOVÁ, Pavel VENTRUBA et. al.

Basic information

Original name

Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins

Authors

JEŠETA, Michal (203 Czech Republic, belonging to the institution), Anna POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution), Lenka MEKIŇOVÁ (703 Slovakia, belonging to the institution), Kateřina FRANZOVÁ (203 Czech Republic, belonging to the institution), Pavel VENTRUBA (203 Czech Republic, belonging to the institution), Eva LOUSOVÁ (203 Czech Republic, belonging to the institution), Bartosz KEMPISTY (616 Poland), Tomáš OŽDIAN (203 Czech Republic), Jana ŽÁKOVÁ (203 Czech Republic, belonging to the institution) and Igor CRHA (203 Czech Republic, belonging to the institution)

Edition

Diagnostics, Basel, MDPI, 2023, 2075-4418

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30214 Obstetrics and gynaecology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.600 in 2022

RIV identification code

RIV/00216224:14110/23:00131350

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/diagnostics13152468

UT WoS

001045385400001

Keywords in English

spermatozoa; azoospermia; sperm isolation; sperm analyses

Abstract

V originále

The compounds of seminal plasma have great potential as biomarkers of male fertility and can be used as a diagnostic tool for types of azoospermia. Azoospermia occurs in approximately 1% of the male population, and for an effective therapy of this form of male infertility, it is important to distinguish between obstructive and non-obstructive azoospermia. Proteins in seminal plasma can serve as biomarkers for diagnosing azoospermia. Considering the various types of obstructions, a combination of multiple proteins is advisable for diagnostic purposes. In this context, testicular and epididymal proteins are particularly significant, as they are specific to these tissues and typically absent in ejaculate during most obstructions. A combination of multiple biomarkers is more effective than the analysis of a single protein. This group of markers contains TEX101 and ECM1 proteins, combined detections of these two bring a diagnostic output with a high sensitivity and specificity. Similar results were observed for combined detection of TEX101 and SPAG1. The effective using of specific biomarkers from seminal plasma can significantly improve the existing approaches to diagnosis of the causes of male infertility.

Citovat

JEŠETA, Michal, Anna POSPÍŠILOVÁ, Lenka MEKIŇOVÁ, Kateřina FRANZOVÁ, Pavel VENTRUBA, Eva LOUSOVÁ, Bartosz KEMPISTY, Tomáš OŽDIAN, Jana ŽÁKOVÁ and Igor CRHA. Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins. Diagnostics. Basel: MDPI, 2023, vol. 13, No 15, p. 1-15. ISSN 2075-4418. Available from: https://dx.doi.org/10.3390/diagnostics13152468.

@article{2300444,
   author = {Ješeta, Michal and Pospíšilová, Anna and Mekiňová, Lenka and Franzová, Kateřina and Ventruba, Pavel and Lousová, Eva and Kempisty, Bartosz and Oždian, Tomáš and Žáková, Jana and Crha, Igor},
   article_location = {Basel},
   article_number = {15},
   doi = {http://dx.doi.org/10.3390/diagnostics13152468},
   keywords = {spermatozoa; azoospermia; sperm isolation; sperm analyses},
   language = {eng},
   issn = {2075-4418},
   journal = {Diagnostics},
   title = {Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins},
   url = {https://www.mdpi.com/2075-4418/13/15/2468},
   volume = {13},
   year = {2023}
}

TY  - JOUR
ID  - 2300444
AU  - Ješeta, Michal - Pospíšilová, Anna - Mekiňová, Lenka - Franzová, Kateřina - Ventruba, Pavel - Lousová, Eva - Kempisty, Bartosz - Oždian, Tomáš - Žáková, Jana - Crha, Igor
PY  - 2023
TI  - Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins
JF  - Diagnostics
VL  - 13
IS  - 15
SP  - 1-15
EP  - 1-15
PB  - MDPI
SN  - 20754418
KW  - spermatozoa
KW  - azoospermia
KW  - sperm isolation
KW  - sperm analyses
UR  - https://www.mdpi.com/2075-4418/13/15/2468
N2  - The compounds of seminal plasma have great potential as biomarkers of male fertility and can be used as a diagnostic tool for types of azoospermia. Azoospermia occurs in approximately 1% of the male population, and for an effective therapy of this form of male infertility, it is important to distinguish between obstructive and non-obstructive azoospermia. Proteins in seminal plasma can serve as biomarkers for diagnosing azoospermia. Considering the various types of obstructions, a combination of multiple proteins is advisable for diagnostic purposes. In this context, testicular and epididymal proteins are particularly significant, as they are specific to these tissues and typically absent in ejaculate during most obstructions. A combination of multiple biomarkers is more effective than the analysis of a single protein. This group of markers contains TEX101 and ECM1 proteins, combined detections of these two bring a diagnostic output with a high sensitivity and specificity. Similar results were observed for combined detection of TEX101 and SPAG1. The effective using of specific biomarkers from seminal plasma can significantly improve the existing approaches to diagnosis of the causes of male infertility.
ER  -

JEŠETA, Michal, Anna POSPÍŠILOVÁ, Lenka MEKIŇOVÁ, Kateřina FRANZOVÁ, Pavel VENTRUBA, Eva LOUSOVÁ, Bartosz KEMPISTY, Tomáš OŽDIAN, Jana ŽÁKOVÁ and Igor CRHA. Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins. \textit{Diagnostics}. Basel: MDPI, 2023, vol.~13, No~15, p.~1-15. ISSN~2075-4418. Available from: https://dx.doi.org/10.3390/diagnostics13152468.

Detailed Information on Publication Record