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@article{2300517, author = {Nottmeier, Cita and Lavický, Josef and González López, Marcos and Knauth, Sarah and KahlandNieke, Baerbel and Amling, Michael and Schinke, Thorsten and Helms, Jill and Křivánek, Jan and Koehne, Till and Petersen, Julian}, article_location = {Berlin}, article_number = {1}, doi = {http://dx.doi.org/10.1038/s41598-023-36699-9}, keywords = {Mechanical-induced bone remodeling; Piezo1; dentoalveolar hard tissue}, language = {eng}, issn = {2045-2322}, journal = {Scientific Reports}, title = {Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue}, url = {https://www.nature.com/articles/s41598-023-36699-9}, volume = {13}, year = {2023} }
TY - JOUR ID - 2300517 AU - Nottmeier, Cita - Lavický, Josef - González López, Marcos - Knauth, Sarah - Kahl-Nieke, Baerbel - Amling, Michael - Schinke, Thorsten - Helms, Jill - Křivánek, Jan - Koehne, Till - Petersen, Julian PY - 2023 TI - Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue JF - Scientific Reports VL - 13 IS - 1 SP - 1-9 EP - 1-9 PB - NATURE RESEARCH SN - 20452322 KW - Mechanical-induced bone remodeling KW - Piezo1 KW - dentoalveolar hard tissue UR - https://www.nature.com/articles/s41598-023-36699-9 N2 - Mechanosensory ion channels are proteins that are sensitive to mechanical forces. They are found in tissues throughout the body and play an important role in bone remodeling by sensing changes in mechanical stress and transmitting signals to bone-forming cells. Orthodontic tooth movement (OTM) is a prime example of mechanically induced bone remodeling. However, the cell-specific role of the ion channels Piezo1 and Piezo2 in OTM has not been investigated yet. Here we first identify the expression of PIEZO1/2 in the dentoalveolar hard tissues. Results showed that PIEZO1 was expressed in odontoblasts, osteoblasts, and osteocytes, while PIEZO2 was localized in odontoblasts and cementoblasts. We therefore used a Piezo1(floxed/floxed) mouse model in combination with Dmp1(cre) to inactivate Piezo1 in mature osteoblasts/cementoblasts, osteocytes/cementocytes, and odontoblasts. Inactivation of Piezo1 in these cells did not affect the overall morphology of the skull but caused significant bone loss in the craniofacial skeleton. Histological analysis revealed a significantly increased number of osteoclasts in Piezo1(floxed/floxed);Dmp1(cre) mice, while osteoblasts were not affected. Despite this increased number of osteoclasts, orthodontic tooth movement was not altered in these mice. Our results suggest that despite Piezo1 being crucial for osteoclast function, it may be dispensable for mechanical sensing of bone remodeling. ER -
NOTTMEIER, Cita, Josef LAVICKÝ, Marcos GONZÁLEZ LÓPEZ, Sarah KNAUTH, Baerbel KAHL-NIEKE, Michael AMLING, Thorsten SCHINKE, Jill HELMS, Jan KŘIVÁNEK, Till KOEHNE and Julian PETERSEN. Mechanical-induced bone remodeling does not depend on Piezo1 in dentoalveolar hard tissue. \textit{Scientific Reports}. Berlin: NATURE RESEARCH, 2023, vol.~13, No~1, p.~1-9. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-023-36699-9.
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