Building an International One Health Strain Level Database to
Characterise the Epidemiology of AMR Threats: ESBL—AmpC
Producing E. coli as An Example—Challenges and Perspectives

J 2023

Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives

PERESTRELO, S., A. AMARO, M. S. BROUWER, L. CLEMENTE, A. S. RIBEIRO DUARTE et. al.

Basic information

Original name

Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives

Authors

PERESTRELO, S., A. AMARO, M. S. BROUWER, L. CLEMENTE, A. S. RIBEIRO DUARTE, A. KAESBOHRER, Renata KARPÍŠKOVÁ (203 Czech Republic, belonging to the institution), V. LOPEZ-CHAVARRIAS, D. MORRIS, D. PRENDERGAST, A. PISTA, L. SILVEIRA, M. SKARZYNSKA, R. SLOWEY, Kees T. VELDMAN, M. ZAJAC, C. BURGESS and J. ALVAREZ

Edition

Antibiotics, Basel, MDPI, 2023, 2079-6382

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.800 in 2022

RIV identification code

RIV/00216224:14110/23:00131376

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/antibiotics12030552

UT WoS

000954023100001

Keywords in English

Escherichia coli; extended-spectrum beta lactamase (ESBL); AmpC beta-lactemase (AmpC); One health; monitoring

Abstract

V originále

Antimicrobial resistance (AMR) is one of the top public health threats nowadays. Among the most important AMR pathogens, Escherichia coli resistant to extended spectrum cephalosporins (ESC-EC) is a perfect example of the One Health problem due to its global distribution in animal, human, and environmental sources and its resistant phenotype, derived from the carriage of plasmid-borne extended-spectrum and AmpC beta-lactamases, which limits the choice of effective antimicrobial therapies. The epidemiology of ESC-EC infection is complex as a result of the multiple possible sources involved in its transmission, and its study would require databases ideally comprising information from animal (livestock, companion, wildlife), human, and environmental sources. Here, we present the steps taken to assemble a database with phenotypic and genetic information on 10,763 ESC-EC isolates retrieved from multiple sources provided by 13 partners located in eight European countries, in the frame of the DiSCoVeR Joint Research project funded by the One Health European Joint Programme (OH-EJP), along with its strengths and limitations. This database represents a first step to help in the assessment of different geographical and temporal trends and transmission dynamics in animals and humans. The work performed highlights aspects that should be considered in future international efforts, such as the one presented here.

Citovat

PERESTRELO, S., A. AMARO, M. S. BROUWER, L. CLEMENTE, A. S. RIBEIRO DUARTE, A. KAESBOHRER, Renata KARPÍŠKOVÁ, V. LOPEZ-CHAVARRIAS, D. MORRIS, D. PRENDERGAST, A. PISTA, L. SILVEIRA, M. SKARZYNSKA, R. SLOWEY, Kees T. VELDMAN, M. ZAJAC, C. BURGESS and J. ALVAREZ. Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives. Antibiotics. Basel: MDPI, 2023, vol. 12, No 3, p. 1-18. ISSN 2079-6382. Available from: https://dx.doi.org/10.3390/antibiotics12030552.

@article{2301521,
   author = {Perestrelo, S. and Amaro, A. and Brouwer, M. S. and Clemente, L. and Ribeiro Duarte, A. S. and Kaesbohrer, A. and Karpíšková, Renata and LopezandChavarrias, V. and Morris, D. and Prendergast, D. and Pista, A. and Silveira, L. and Skarzynska, M. and Slowey, R. and Veldman, Kees T. and Zajac, M. and Burgess, C. and Alvarez, J.},
   article_location = {Basel},
   article_number = {3},
   doi = {http://dx.doi.org/10.3390/antibiotics12030552},
   keywords = {Escherichia coli; extended-spectrum beta lactamase (ESBL); AmpC beta-lactemase (AmpC); One health; monitoring},
   language = {eng},
   issn = {2079-6382},
   journal = {Antibiotics},
   title = {Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives},
   url = {https://www.mdpi.com/2079-6382/12/3/552},
   volume = {12},
   year = {2023}
}

TY  - JOUR
ID  - 2301521
AU  - Perestrelo, S. - Amaro, A. - Brouwer, M. S. - Clemente, L. - Ribeiro Duarte, A. S. - Kaesbohrer, A. - Karpíšková, Renata - Lopez-Chavarrias, V. - Morris, D. - Prendergast, D. - Pista, A. - Silveira, L. - Skarzynska, M. - Slowey, R. - Veldman, Kees T. - Zajac, M. - Burgess, C. - Alvarez, J.
PY  - 2023
TI  - Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives
JF  - Antibiotics
VL  - 12
IS  - 3
SP  - 1-18
EP  - 1-18
PB  - MDPI
SN  - 20796382
KW  - Escherichia coli
KW  - extended-spectrum beta lactamase (ESBL)
KW  - AmpC beta-lactemase (AmpC)
KW  - One health
KW  - monitoring
UR  - https://www.mdpi.com/2079-6382/12/3/552
N2  - Antimicrobial resistance (AMR) is one of the top public health threats nowadays. Among the most important AMR pathogens, Escherichia coli resistant to extended spectrum cephalosporins (ESC-EC) is a perfect example of the One Health problem due to its global distribution in animal, human, and environmental sources and its resistant phenotype, derived from the carriage of plasmid-borne extended-spectrum and AmpC beta-lactamases, which limits the choice of effective antimicrobial therapies. The epidemiology of ESC-EC infection is complex as a result of the multiple possible sources involved in its transmission, and its study would require databases ideally comprising information from animal (livestock, companion, wildlife), human, and environmental sources. Here, we present the steps taken to assemble a database with phenotypic and genetic information on 10,763 ESC-EC isolates retrieved from multiple sources provided by 13 partners located in eight European countries, in the frame of the DiSCoVeR Joint Research project funded by the One Health European Joint Programme (OH-EJP), along with its strengths and limitations. This database represents a first step to help in the assessment of different geographical and temporal trends and transmission dynamics in animals and humans. The work performed highlights aspects that should be considered in future international efforts, such as the one presented here.
ER  -

PERESTRELO, S., A. AMARO, M. S. BROUWER, L. CLEMENTE, A. S. RIBEIRO DUARTE, A. KAESBOHRER, Renata KARPÍŠKOVÁ, V. LOPEZ-CHAVARRIAS, D. MORRIS, D. PRENDERGAST, A. PISTA, L. SILVEIRA, M. SKARZYNSKA, R. SLOWEY, Kees T. VELDMAN, M. ZAJAC, C. BURGESS and J. ALVAREZ. Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives. \textit{Antibiotics}. Basel: MDPI, 2023, vol.~12, No~3, p.~1-18. ISSN~2079-6382. Available from: https://dx.doi.org/10.3390/antibiotics12030552.

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