Detailed Information on Publication Record
2023
Effects of goal-directed fluid management guided by a non-invasive device on the incidence of postoperative complications in neurosurgery: a pilot and feasibility randomized controlled trial
HRDÝ, Ondřej, Miloš DUBA, Andrea DOLEZELOVA, Ivana ROŠKOVÁ, Martin HLAVATÝ et. al.Basic information
Original name
Effects of goal-directed fluid management guided by a non-invasive device on the incidence of postoperative complications in neurosurgery: a pilot and feasibility randomized controlled trial
Authors
HRDÝ, Ondřej (203 Czech Republic, belonging to the institution), Miloš DUBA (203 Czech Republic, guarantor, belonging to the institution), Andrea DOLEZELOVA (203 Czech Republic), Ivana ROŠKOVÁ (703 Slovakia, belonging to the institution), Martin HLAVATÝ (203 Czech Republic, belonging to the institution), Rudolf TRAJ (703 Slovakia, belonging to the institution), Vít BÖNISCH (203 Czech Republic, belonging to the institution), Martin SMRČKA (203 Czech Republic, belonging to the institution) and Roman GÁL (203 Czech Republic, belonging to the institution)
Edition
PERIOPERATIVE MEDICINE, London, BMC, 2023, 2047-0525
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30212 Surgery
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.600 in 2022
RIV identification code
RIV/00216224:14110/23:00131383
Organization unit
Faculty of Medicine
UT WoS
001019955700001
Keywords in English
Complications; Goal-directed therapy; Hemodynamic monitoring; Neuro-anesthesia; Neurosurgery; Postoperative outcome
Tags
International impact, Reviewed
Změněno: 9/8/2023 08:25, Mgr. Tereza Miškechová
Abstract
V originále
BackgroundThe positive effects of goal-directed hemodynamic therapy (GDHT) on patient-orientated outcomes have been demonstrated in various clinical scenarios; however, the effects of fluid management in neurosurgery remain unclear. Therefore, this study was aimed at assessing the safety and feasibility of GDHT using non-invasive hemodynamic monitoring in elective neurosurgery. The incidence of postoperative complications was compared between GDHT and control groups.MethodsWe conducted a single-center randomized pilot study with an enrollment target of 34 adult patients scheduled for elective neurosurgery. We randomly assigned the patients equally into control and GDHT groups. The control group received standard therapy during surgery and postoperatively, whereas the GDHT group received therapy guided by an algorithm based on non-invasive hemodynamic monitoring. In the GDHT group, we aimed to achieve and sustain an optimal cardiac index by using non-invasive hemodynamic monitoring and bolus administration of colloids and vasoactive drugs. The number of patients with adverse events, feasibility criteria, perioperative parameters, and incidence of postoperative complications was compared between groups.ResultsWe successfully achieved all feasibility criteria. The GDHT protocol was safe, because no patients in either group had unsatisfactory brain tissue relaxation after surgery or brain edema requiring therapy during surgery or 24 h after surgery. Major complications occurred in two (11.8%) patients in the GDHT group and six (35.3%) patients in the control group (p = 0.105).ConclusionsOur results suggested that a large randomized trial evaluating the effects of GDHT on the incidence of postoperative complications in elective neurosurgery should be safe and feasible. The rate of postoperative complications was comparable between groups.
Links
| MUNI/A/1421/2022, interní kód MU |
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