Genetics of T2DM and Its Chronic Complications: Are We Any
Closer to the Individual Prediction of Genetic Risk?

J 2022

Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk?

GALUŠKA, David; Lucie DLOUHÁ; Jaroslav HUBÁČEK and Kateřina KAŇKOVÁ

Basic information

Original name

Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk?

Authors

GALUŠKA, David (203 Czech Republic, belonging to the institution); Lucie DLOUHÁ (203 Czech Republic, guarantor); Jaroslav HUBÁČEK (203 Czech Republic) and Kateřina KAŇKOVÁ (203 Czech Republic, belonging to the institution)

Edition

FOLIA BIOLOGICA, PRAGUE, CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE, 2022, 0015-5500

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30101 Human genetics

Country of publisher

Czech Republic

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 0.600

RIV identification code

RIV/00216224:14110/22:00134644

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.14712/fb2022068050159

UT WoS

001010557100001

EID Scopus

2-s2.0-85160966420

Keywords in English

diabetes mellitus; diabetes complication; polymorphism; Central European population; genetic; GWAS; diabetic neuropathy; diabetic kidney disease; diabetic retinopathy; cardiovascular disease

Abstract

In the original language

Type 2 diabetes mellitus (T2DM) is a com-plex disease that has risen in global prevalence over recent decades, resulting in concomitant and enor-mous socio-economic impacts. In addition to the well-documented risk factors of obesity, poor dietary habits and sedentary lifestyles, genetic background plays a key role in the aetiopathogenesis of diabetes and the development of associated micro-and macro -vascular complications. Recent advances in genomic research, notably next-generation sequencing and ge-nome-wide association studies, have greatly improved the efficiency with which genetic backgrounds to com-plex diseases are analysed. To date, several hundred single-nucleotide polymorphisms have been associ-ated with T2DM or its complications. Given the poly -genic background to T2DM (and numerous other complex diseases), the degree of genetic predisposi-tion can be treated as a "continuous trait" quantified by a genetic risk score. Focusing mainly on the Central European population, this review summa-rizes recent state-of-the-art methods that have en-abled us to better determine the genetic architecture of T2DM and the utility of genetic risk scores in dis-ease prediction.

Links

NV18-01-00046, research and development project

Name: Genetické skóre v predikci rizika diabetu a jeho komplikací

Investor: Ministry of Health of the CR

Cite

GALUŠKA, David; Lucie DLOUHÁ; Jaroslav HUBÁČEK and Kateřina KAŇKOVÁ. Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk? FOLIA BIOLOGICA. PRAGUE: CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE, 2022, vol. 68, 5-6, p. 159-179. ISSN 0015-5500. Available from: https://dx.doi.org/10.14712/fb2022068050159.

@article{2301606,
   author = {Galuška, David and Dlouhá, Lucie and Hubáček, Jaroslav and Kaňková, Kateřina},
   article_location = {PRAGUE},
   article_number = {5-6},
   doi = {http://dx.doi.org/10.14712/fb2022068050159},
   keywords = {diabetes mellitus; diabetes complication; polymorphism; Central European population; genetic; GWAS; diabetic neuropathy; diabetic kidney disease; diabetic retinopathy; cardiovascular disease},
   language = {eng},
   issn = {0015-5500},
   journal = {FOLIA BIOLOGICA},
   title = {Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk?},
   url = {https://fb.littledata.cz/68/5/0159/},
   volume = {68},
   year = {2022}
}

TY  - JOUR
ID  - 2301606
AU  - Galuška, David - Dlouhá, Lucie - Hubáček, Jaroslav - Kaňková, Kateřina
PY  - 2022
TI  - Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk?
JF  - FOLIA BIOLOGICA
VL  - 68
IS  - 5-6
SP  - 159-179
EP  - 159-179
PB  - CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE
SN  - 00155500
KW  - diabetes mellitus
KW  - diabetes complication
KW  - polymorphism
KW  - Central European population
KW  - genetic
KW  - GWAS
KW  - diabetic neuropathy
KW  - diabetic kidney disease
KW  - diabetic retinopathy
KW  - cardiovascular disease
UR  - https://fb.littledata.cz/68/5/0159/
N2  - Type 2 diabetes mellitus (T2DM) is a com-plex disease that has risen in global prevalence over recent decades, resulting in concomitant and enor-mous socio-economic impacts. In addition to the well-documented risk factors of obesity, poor dietary habits and sedentary lifestyles, genetic background plays a key role in the aetiopathogenesis of diabetes and the development of associated micro-and macro -vascular complications. Recent advances in genomic research, notably next-generation sequencing and ge-nome-wide association studies, have greatly improved the efficiency with which genetic backgrounds to com-plex diseases are analysed. To date, several hundred single-nucleotide polymorphisms have been associ-ated with T2DM or its complications. Given the poly -genic background to T2DM (and numerous other complex diseases), the degree of genetic predisposi-tion can be treated as a "continuous trait" quantified by a genetic risk score. Focusing mainly on the Central European population, this review summa-rizes recent state-of-the-art methods that have en-abled us to better determine the genetic architecture of T2DM and the utility of genetic risk scores in dis-ease prediction.
ER  -

GALUŠKA, David; Lucie DLOUHÁ; Jaroslav HUBÁČEK and Kateřina KAŇKOVÁ. Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk? \textit{FOLIA BIOLOGICA}. PRAGUE: CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE, 2022, vol.~68, 5-6, p.~159-179. ISSN~0015-5500. Available from: https://dx.doi.org/10.14712/fb2022068050159.

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