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@article{2301606, author = {Galuška, David and Dlouhá, Lucie and Hubáček, Jaroslav and Kaňková, Kateřina}, article_location = {PRAGUE}, article_number = {5-6}, doi = {http://dx.doi.org/10.14712/fb2022068050159}, keywords = {diabetes mellitus; diabetes complication; polymorphism; Central European population; genetic; GWAS; diabetic neuropathy; diabetic kidney disease; diabetic retinopathy; cardiovascular disease}, language = {eng}, issn = {0015-5500}, journal = {FOLIA BIOLOGICA}, title = {Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk?}, url = {https://fb.littledata.cz/68/5/0159/}, volume = {68}, year = {2022} }
TY - JOUR ID - 2301606 AU - Galuška, David - Dlouhá, Lucie - Hubáček, Jaroslav - Kaňková, Kateřina PY - 2022 TI - Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk? JF - FOLIA BIOLOGICA VL - 68 IS - 5-6 SP - 159-179 EP - 159-179 PB - CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE SN - 00155500 KW - diabetes mellitus KW - diabetes complication KW - polymorphism KW - Central European population KW - genetic KW - GWAS KW - diabetic neuropathy KW - diabetic kidney disease KW - diabetic retinopathy KW - cardiovascular disease UR - https://fb.littledata.cz/68/5/0159/ N2 - Type 2 diabetes mellitus (T2DM) is a com-plex disease that has risen in global prevalence over recent decades, resulting in concomitant and enor-mous socio-economic impacts. In addition to the well-documented risk factors of obesity, poor dietary habits and sedentary lifestyles, genetic background plays a key role in the aetiopathogenesis of diabetes and the development of associated micro-and macro -vascular complications. Recent advances in genomic research, notably next-generation sequencing and ge-nome-wide association studies, have greatly improved the efficiency with which genetic backgrounds to com-plex diseases are analysed. To date, several hundred single-nucleotide polymorphisms have been associ-ated with T2DM or its complications. Given the poly -genic background to T2DM (and numerous other complex diseases), the degree of genetic predisposi-tion can be treated as a "continuous trait" quantified by a genetic risk score. Focusing mainly on the Central European population, this review summa-rizes recent state-of-the-art methods that have en-abled us to better determine the genetic architecture of T2DM and the utility of genetic risk scores in dis-ease prediction. ER -
GALUŠKA, David, Lucie DLOUHÁ, Jaroslav HUBÁČEK and Kateřina KAŇKOVÁ. Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk? \textit{FOLIA BIOLOGICA}. PRAGUE: CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE, 2022, vol.~68, 5-6, p.~159-179. ISSN~0015-5500. Available from: https://dx.doi.org/10.14712/fb2022068050159.
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