Genetics of T2DM and Its Chronic Complications: Are We Any
Closer to the Individual Prediction of Genetic Risk?

J 2022

Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk?

GALUŠKA, David, Lucie DLOUHÁ, Jaroslav HUBÁČEK and Kateřina KAŇKOVÁ

Basic information

Original name

Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk?

Authors

GALUŠKA, David (203 Czech Republic, belonging to the institution), Lucie DLOUHÁ (203 Czech Republic, guarantor), Jaroslav HUBÁČEK (203 Czech Republic) and Kateřina KAŇKOVÁ (203 Czech Republic, belonging to the institution)

Edition

FOLIA BIOLOGICA, PRAGUE, CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE, 2022, 0015-5500

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30101 Human genetics

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 0.600

RIV identification code

RIV/00216224:14110/22:00134644

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.14712/fb2022068050159

UT WoS

001010557100001

Keywords in English

diabetes mellitus; diabetes complication; polymorphism; Central European population; genetic; GWAS; diabetic neuropathy; diabetic kidney disease; diabetic retinopathy; cardiovascular disease

Abstract

V originále

Type 2 diabetes mellitus (T2DM) is a com-plex disease that has risen in global prevalence over recent decades, resulting in concomitant and enor-mous socio-economic impacts. In addition to the well-documented risk factors of obesity, poor dietary habits and sedentary lifestyles, genetic background plays a key role in the aetiopathogenesis of diabetes and the development of associated micro-and macro -vascular complications. Recent advances in genomic research, notably next-generation sequencing and ge-nome-wide association studies, have greatly improved the efficiency with which genetic backgrounds to com-plex diseases are analysed. To date, several hundred single-nucleotide polymorphisms have been associ-ated with T2DM or its complications. Given the poly -genic background to T2DM (and numerous other complex diseases), the degree of genetic predisposi-tion can be treated as a "continuous trait" quantified by a genetic risk score. Focusing mainly on the Central European population, this review summa-rizes recent state-of-the-art methods that have en-abled us to better determine the genetic architecture of T2DM and the utility of genetic risk scores in dis-ease prediction.

Links

NV18-01-00046, research and development project

Name: Genetické skóre v predikci rizika diabetu a jeho komplikací

Investor: Ministry of Health of the CR

Citovat

GALUŠKA, David, Lucie DLOUHÁ, Jaroslav HUBÁČEK and Kateřina KAŇKOVÁ. Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk? FOLIA BIOLOGICA. PRAGUE: CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE, 2022, vol. 68, 5-6, p. 159-179. ISSN 0015-5500. Available from: https://dx.doi.org/10.14712/fb2022068050159.

@article{2301606,
   author = {Galuška, David and Dlouhá, Lucie and Hubáček, Jaroslav and Kaňková, Kateřina},
   article_location = {PRAGUE},
   article_number = {5-6},
   doi = {http://dx.doi.org/10.14712/fb2022068050159},
   keywords = {diabetes mellitus; diabetes complication; polymorphism; Central European population; genetic; GWAS; diabetic neuropathy; diabetic kidney disease; diabetic retinopathy; cardiovascular disease},
   language = {eng},
   issn = {0015-5500},
   journal = {FOLIA BIOLOGICA},
   title = {Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk?},
   url = {https://fb.littledata.cz/68/5/0159/},
   volume = {68},
   year = {2022}
}

TY  - JOUR
ID  - 2301606
AU  - Galuška, David - Dlouhá, Lucie - Hubáček, Jaroslav - Kaňková, Kateřina
PY  - 2022
TI  - Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk?
JF  - FOLIA BIOLOGICA
VL  - 68
IS  - 5-6
SP  - 159-179
EP  - 159-179
PB  - CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE
SN  - 00155500
KW  - diabetes mellitus
KW  - diabetes complication
KW  - polymorphism
KW  - Central European population
KW  - genetic
KW  - GWAS
KW  - diabetic neuropathy
KW  - diabetic kidney disease
KW  - diabetic retinopathy
KW  - cardiovascular disease
UR  - https://fb.littledata.cz/68/5/0159/
N2  - Type 2 diabetes mellitus (T2DM) is a com-plex disease that has risen in global prevalence over recent decades, resulting in concomitant and enor-mous socio-economic impacts. In addition to the well-documented risk factors of obesity, poor dietary habits and sedentary lifestyles, genetic background plays a key role in the aetiopathogenesis of diabetes and the development of associated micro-and macro -vascular complications. Recent advances in genomic research, notably next-generation sequencing and ge-nome-wide association studies, have greatly improved the efficiency with which genetic backgrounds to com-plex diseases are analysed. To date, several hundred single-nucleotide polymorphisms have been associ-ated with T2DM or its complications. Given the poly -genic background to T2DM (and numerous other complex diseases), the degree of genetic predisposi-tion can be treated as a "continuous trait" quantified by a genetic risk score. Focusing mainly on the Central European population, this review summa-rizes recent state-of-the-art methods that have en-abled us to better determine the genetic architecture of T2DM and the utility of genetic risk scores in dis-ease prediction.
ER  -

GALUŠKA, David, Lucie DLOUHÁ, Jaroslav HUBÁČEK and Kateřina KAŇKOVÁ. Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk? \textit{FOLIA BIOLOGICA}. PRAGUE: CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE, 2022, vol.~68, 5-6, p.~159-179. ISSN~0015-5500. Available from: https://dx.doi.org/10.14712/fb2022068050159.

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